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>Home >FACULTY> Hsueh-Fen Juan , Professor
Hsueh-Fen Juan , Professor
 
Professor

Born in 1969

Ph. D. NationalTaiwanUniversity
Specialty Bioinformatics, Genomic, Proteomics

E-mail : yukijuan@ntu.edu.tw

Laboratory: Life Science Building R1105

TEL 886-2- 33664536

Recent Research Topics
  • Evolution and functions of microRNAs that regulate ATP synthase subunit genes .
  • Gene network of host cell by Helicobacter: annexin A4 involved singalling and regulation in gastric cancer .
  • Applying systems biology for anti-lung cancer drug discovery: targeting therapy by ATP synthase inhibitors and molecular mechanism study .

Laboratory: Systems Biology Laboratory

Systems Biology Laboratory

  Systems biology is a new field that focuses on understanding biological processes and their functional activities from a system-wide perspective. With the advent of high-throughput omics technologies and computational methods, systems biology has become a viable approach to improve our knowledge of health and disease. This holistic approach will enable more rapid advances in elucidating biomolecular pathways and identifying targets for drug discovery and disease therapies. To integrate the data generated from omics technologies, there is much academic focus on developing fundamental computational and informatics tools into models of regulatory networks and cell behavior. Classic bench-top experiments are used hand in hand to provide high-throughput data and to validate simulated predictions. Through an iterative process of experimental assays, data analyses and computational simulations, in silico models are refined so as to more closely reflect the biological reality. The main research in our lab is to apply systems biology for drug discovery and investigate the molecular mechanism of the drugs in cancer cells.

  Targeting tumor tissues is one of the most powerful approaches to accelerate the efficiency of anticancer treatments. We discovered a novel anti-cancer drug for targeting therapy. This finding, described as the first to test possible medical uses of so-called ATP-synthase inhibitors, may lead to new and more effective anti-cancer medications. Additionally, we elucidated the mechanism of anti-cancer novel drugs, sialyltransferase inhibitor, OSU03013 and cRGD. Our findings show their potential to be anticancer drugs and this information presents a valuable in-depth description of their possible impact on cancer therapy.

  MicroRNAs are short single-stranded non-coding RNA molecules which play a key role in post-transcriptional regulation of mRNAs. A miRNA can affect many downstream targets which in turn form a complicated network. Our lab has characterized the roles of miRNAs in the regulation of cellular networks and revealed that miRNA-regulated network could be used as a novel therapeutic target for cancer as well as other diseases such as neurological and cardiovascular diseases.

Selected Research Publications

Journal Papers:

  1. Hsieh, L.-C., Chen, J.-W., Wang, L.-Y., Tsang, Y.-M., Shueng, P.-W., Liao, L.-J., Lo, W.-C., Lin, Y.-C., Tseng, C.-F., Kuo, Y.-S., Jhuang, J.-Y., Tien, H.-J., Juan, H.-F. , Hsieh, C.-H. (2014) "Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging" PLoS ONE 9(3):e92561.
  2. Huang, W.-J., Tang, Y.-A., Chen, M.-Y, Wang, Y.-J., Hu, F.-H., Wang, T.-W., Chao, S.-W. Chiu, H.-W., Yeh, Y.-L., Chang, H.-Y., Juan, H.-F. , Lin, P. * , and Wang, Y.-C. * (2014) "A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies" Cancer Letter 346(1):84-93.
  3. Wu, P.-Y., Liao, Y.-F., Juan, H.-F. , Huang, H.-C., Wang, B.-J., Lu, Y.-L., Yu, I-S., Shih, Y.-Y., Jeng, Y.-M., Hsu, W.-M. * , and Lee, H. * (2014) "Aryl hydrocarbon receptor downregulates mycn expression and promotes cell differentiation of neuroblastoma" PLoS ONE 9(2): e88795.
  4. Chang, H.-Y., Shih, M.-H., Huang, H.-C., Tsai, S.-R., Juan, H.-F. * , Lee, S.-C. * (2013) "Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells" PLoS ONE 8(1): e54117. ( Featured on PLoS Blog )
  5. Hu, C.-W., Tseng, C.-W., Chien, C.-W., Huang, H.-C., Ku, W.-C., Lee, S.-J. * , Chen, Y.-J. * and Juan, H.-F. * (2013) "Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development" Journal of Proteome Research 12(9):3993-4004.
  6. Wu, Y.-H., Hu, C.-W., Chien, C.-W., Chen, Y.-J., Huang, H.-C.* and Juan, H.-F.* (2013) "Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin" PLoS ONE 8(8):e70642.
  7. Lin, L.-L., Wu, C.-C., Huang, H.-C. * , Chen, H.-J. Hsieh, H.-L. * , and Juan, H.-F. * (2013) "Identification of microRNA 395a in 24-epibrassinolide-regulated root growth of Arabidopsis thaliana using microRNA arrays" International Journal of Molecular Sciences 14:14270-14286.
  8. Lin, C.-C., Lee, C.-H., Fuh, C.-S., Juan, H.-F. * and Huang, H.-C. * (2013) "Link clustering reveals structural characteristics and biological contexts in signed molecular networks" PLoS ONE 8(6): e67089.
  9. Lee, C.-H., Kuo, W.-H., Lin, C.-C., Oyang, Y.-J., Huang, H.-C. * and Juan, H.-F. * (2013) "MicroRNA-regulated protein-protein interaction networks and their functions in breast cancer" International Journal of Molecular Sciences 14:11560-11606.
  10. Liaw, H.-H., Lin, C.-C., Juan, H.-F. * and Huang, H.-C. * (2013) "Differential microRNA regulation correlates with alternative polyadenylation pattern between breast cancer and normal cells" PLoS ONE 8(2): e56958.
  11. Fu, S.-C., Huang, H.-C., Horton, P.* and Juan, H.-F. * (2013) "ValidNESs: a database of validated leucine-rich nuclear export signals" Nucleic Acids Research 41(D1):D338-D343.
  12. Lin, L.-L., Huang, H.-C., Ogihara, S., Wang, J.-T., Wu, M.-C., McNeil, P. L. * , Chen, C.-N. * and Juan, H.-F. * (2012) " Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation" International Journal of Molecular Sciences 13 : 10176-10192.
  13. Lin, L.-L., Huang, H.-C. * , and Juan, H.-F. * (2012) "Revealing the molecular mechanism of gastric cancer marker Annexin A4 in cancer cell proliferation using exon arrays" PLoS ONE 7(9):e44615.
  14. Chang, H.-Y., Huang, H.-C., Huang, T.-C., Yang, P.-C.*, Wang, Y.-C.*, and Juan, H.-F. * (2012) "Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response" Cancer Research 72(18): 4696-4706.
  15. Lin, L.-L., Huang, H.-C. * and Juan, H.-F. * (2012) "Discovery of biomarkers for gastric cancer: a proteomics approach" Journal of Proteomics 75(11):3081-3097.
  16. Chang, M.-W., Lo, J.-M., Juan, H.-F. , H.-Y. Chang, Chuang, C.-Y. (2012) " Combination of RGD Compound and Low-Dose Paclitaxel Induces Apoptosis in Human Glioblastoma Cells " PLoS ONE 7(5):e37935
  17. Tseng, C.-W., Huang, H.-C., Shih, A. C.-C., Chang, Y.-Y., Hsu, C. C., Chang, J.-Y., Li, W.-H. * and Juan, H.-F. * (2012) "Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D" International Journal of Molecular Sciences 13 :6352-6369.
  18. Lin, C.-C., Chen, Y.-J., Chen, C.-Y., Oyang, Y.-J., Juan, H.-F. * and Huang, H.-C. * (2012) "Crosstalk between transcription factors and microRNAs in human protein interaction network" BMC Systems Biology 6(1):18.
  19. Shih, Y.-Y., Nakagawara, A., Lee, H., Juan, H.-F. , Jeng, Y.-M., Lin, D.-T., Yang, Y.-L., Tsay, Y.-G., Huang, M.-C., Pan, C.-Y. * , Hsu, W.-M. * , and Liao, Y.-F. * (2012) "Calreticulin mediates nerve growth factor-induced neuronal differentiation" Journal of Molecular Neuroscience 47(3):571-81.
  20. Chen, C.-Y., Chen, S.-T., Juan, H.-F. * and Huang, H.-C. * (2012) "Lengthening of 3'UTR increases morphological complexity in animal evolution" Bioinformatics 28(24):3178-3181. (ESI 2013 Highly cited papers) .
  21. Lu, K.-Y., Tao, S.-C., Yang, T.-C., Ho, Y.-H., Lee, C.-H., Lin, C.-C., Juan, H.-F. , Huang, H.-C. , Yang, C.-Y., Chen, M,-S, Zhu, H. * and Chen, C.-S. * (2012) "Profiling lipid-protein interactions using non-quenched fluorescent liposomal nanovesicles and proteome microarrays" Molecular & Cellular Proteomics 11(11):1177-1190.
  22. Hu, C.-W., Lin, M.-H., Huang, H.-C., Ku, W.-C., Yi, T.-H., Tsai, C.-F., Chen, Y.-J., Sugiyama, N., Ishihama, Y. * , Juan, H.-F. * , and Wu, S.-H. * (2012) "Phosphoproteomic analysis of Rhodopseudomonas palustris reveals the role of pyruvate phosphate dikinase phosphorylation in lipid production" Journal of Proteome Research 11:5362-5375.
  23. Lin, L.-L., Wang, Y.-H., Lai, C.-Y., Chau, C.-L., Su, G.-C., Yang, C.-Y., Lou, S.-Y., Chen, S.-K., Hsu, K.-H., Lai, Y.-L., Wu, W.-M., Huang, J.-L., Liao, C.-H. and Juan, H.-F. * (2012) "Systems biology of meridians, acupoints, and Chinese herbs in disease" Evidence-Based Complementary and Alternative Medicine 2012:372670.
  24. Hu, C.-W., Chang, Y.-L., Chen, S. J., Kuo-Huang, L.-L., Liao, J. C., Huang, H.-C.*, Juan, H.-F.* (2011) "Revealing the functions of the transketolase enzyme isoforms in Rhodopseudomonas palustris using a systems biology approach" PLoS ONE 6:e28329.
  25. Huang, T.-C., Chang, H.-Y., Chen, C.-Y., Wu, P.-Y., Lee, H., Liao, Y.-F., Hsu, W.-M.*, Huang, H.-C.*, Juan, H.-F.* (2011) "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR" FEBS Letters 585:3582-3586.
  26. Tsai, S.-R.#, Huang, T.-C.#, Liang, C.-M., Chang, H.-Y., Chang, Y.-T., Huang, H.-C., Juan, H.-F.*, Lee, S.-C.* (2011) "The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli" Applied Physics Letters 99, 163704. (# equal contribution)
  27. Shih, Y.-Y., Pan, C,-Y, Lee, H., Juan, H.-F., A. Nakagawara, Clagett-Dame, M., Tsay, Y.-G., Hsieh, F.-J., Hsu, W.-M.*, Liao, Y.-F. * (2011) "Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma" PLoS ONE 6(10):e26236
  28. Chen, S.-T., Jeng, Y.-M., Chang, C.-C., Chang, H.-H., Huang, M.-C., Juan, H.-F., Hsu, C.-H., Lee, H.-Y., Liao, Y.-F, Lee, Y.-L., Hsu, W.-M.*, Lai, H.-S.* (2011) "Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma" Cancer Science 102:2191-2198.
  29. Lee, C.-H., Huang, H.-C. * , Juan, H.-F. * (2011) "Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor" International Journal of Molecular Sciences 12, 5304-5318.
  30. Chen, C.-M., Lin, C.-H., Juan, H.-F. , Hu, F.-J., Hsiao, Y.-C., Chang, H.-Y., Chao, C.-Y., Chen, I.-C., Lee, L.-C., Wang, T.-W., Chen, Y.-T., Chen, Y.-T., Lee-Chen, G.-J. * , Wu, Y.-R. (2011) ATP13A2 variability in Taiwanese Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 156:720-729.
  31. Tseng, C.-W., Lin, C.-C., Chen, C.-N. * , Huang, H.-C. * , Juan, H.-F. * (2011) "Integrative network analysis reveals active microRNAs and their functions in gastric cancer" BMC Systems Biology 5:99.
  32. Tseng, C.-W., Yang, J.-C., Chen, C.-N. * , Huang, H.-C., Chuang, K.-N., Lin, C.-C., Lai, H.-S., Lee, P.-H., Chang, K.-J., Juan, H.-F. * (2011) " Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker " Proteomics 11:2423-2439.
  33. Chen, J.-Y., Huang, S.-M., Tang, Y.-A., Juan, H.-F. , Wu, L.-W., Sun, Y.-C., Wang, S.-C., Wu, K. W., Balraj, G., Chang, T.-T., Li, W.-S. * , Cheng, H.-C. * , Wang, Y.-C. * (2011) "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis" Cancer Research 71:473-483.
  34. Chen, C-Y, Chen, S.-T., Fuh, C.-S. Juan, H.-F. * , Huang H.-C. * (2011) "Coregulation of Transcription Factors and microRNAs in Transcriptional Regulatory Network" BMC Bioinformatics 12(Suppl 1):S41.
  35. Lin, C.-C., Hsiang, J.-T., Wu, C.-Y., Oyang, Y.-J., Juan, H.-F. * , Huang H.-C. * (2010) "Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy" BMC Systems Biology 4:138.
  36. Chang, H.-H., Lee, H.-Y., Hu, M.-K., Tsao, P.-N., Juan, H.-F. , Huang, M.-C., Shih, Y.-Y., Wang, B.-J., Jeng, Y.-M., Chang, C., Huang, S.-F., Y.-G. Tsay, Hsieh, F.-J., Lin, K.-H. * , Hsu, W.-M. * , and Liao, Y.-F * . (2010) "Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma" Clinical Cancer Research 16:4411-4420.
  37. Hsu, J.-W., Huang H.-C. , Chen, S.-T., Wong, C.-H. , Juan, H.-F. * (2009) " Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation" Evidence-Based Complementary and Alternative Medicine ; doi: 10.1093/ecam/nep107
  38. Hwang Y.-C., Lin C.-C., Chang J.-Y., Mori H., Juan, H.-F. * , Huang H.-C. * (2009) "Predicting essential genes based on network and sequence analysis" Molecular BioSystems 5:1672–1678.
  39. Lin, C.-C., Juan, H.-F. , Hsiang, J.-T., Hwang, Y.-C., Mori, H. * , Huang, H.-C. * (2009) "Essential core of protein-protein interaction network in Escherichia coli " Journal of Proteome Research 8(4):1925-1931.
  40. Chang, Y.-M., Juan, H.-F. , Lee, T.-Y., Chang, Y.-Y., Yeh, Y.-M., Li, W.-H. * , Shih, A. C.-C. (2008) "Prediction of human miRNAs using tissue-selective motifs in 3' UTRs" Proc. Natl. Acad. Sci. U S A 105, 17061-17066. ( Highlighted in Nature Biotechnology and in Science-Business eXchange (SciBX) )
  41. Fang, Y.-C., Huang, H.-C. , Chen, H.-H. and Juan, H.-F. * (2008) "TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining" BMC Complementary and Alternative Medicine 8:58.
  42. W.-M. Hsu, H.-Y. Lee, Juan, H.-F. , Y.-Y. Shih, B-J. Wang, C.-Y. Pan, Y.-M. Jeng, H.-H. Chang, M.-Y. Lu, K.-H. Lin, H.-S. Lai, W.-J. Chen, Y.-G. Tsay * , Y.-F. Liao * , F.-J. Hsieh * (2008) "Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis" Clinical Cancer Research 14:6237-6245.
  43. Hsu, C.-W., Juan, H.-F. * , Huang, H.-C. * (2008) "Characterization of microRNA-Regulated Protein-Protein Interaction Network" Proteomics 8:1975-1979.
  44. Lin, L.-L., C.-N. Chen*, Lin, W.-C., Lee, P.-H., Chang, K.-J., Lai, Y.-P., Wang, J.-T., Juan, H.-F. * (2008) "Annexin A4: A novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach " Proteomics: clinical applications 2:619-634.
  45. Chen, S.-T., Pan, T.-L., Juan, H.-F. , Chen, T.-Y., Lin, Y.-S., Huang, C.-M. * (2008) "Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome and Extracellular Matrix" Journal of Proteome Research 7:1379-1387.
  46. Huang, T.-C., Chang, H.-Y., Hsu, C.-H., Kuo, W.-H., Chang, K.-J., Juan, H.-F. * (2008) "Targeting Therapy on Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B" Journal of Proteome Research 7:1433-1444. ( Science Daily news & American Chemical Society weekly news )
  47. Chen, H.-W., Huang, H.-C., Lin, Y.-S., Chang, K.-J., Kuo, W.-H., Hwa, H.-L., Hsieh, F.-J. * , Juan, H.-F. * (2008) "Comparison and Identification of Estrogen-Receptor Related Gene Expression Profiles in Breast Cancer of Different Ethnic Origins" Breast Cancer: Basic and Clinical Research 1:35-49.
  48. Tan, Y-H., Lee, K.-H., Sun, Y.-C., Juan, H.-F. * , Y.-C. Wang * (2008) "Cytotoxicity and proteomics analyses of OSU 03013 in lung cancer" Clinical Cancer Research 14:1823-1830.
  49. Fang, Y.-C., Huang, H.-C. * , Juan, H.-F. * (2008) "MeInfoText: Associated Gene Methylation and Cancer Information from Text Mining" BMC Bioinformatics 9:22.
  50. Huang, B., Ni, K.-C., Chen, S.-L., Juan, H.-F. * , Chen Y.-M. * (2008) "Elucidating the Growth Regulation of Brassinosteroids in Mung Bean Epicotyls using a Proteomics Approach" Proteomics Research Journal 1: 1-18.
  51. Lien, H.-C., Hsiao, Y.-H., Lin, Y.-S., Yao , Y.-T., Juan, H.-F. , Kuo, W.-H., Hung, M.-C., Chang, K.-J., Hsieh, F.-J. * (2007) "Molecular Signatures of Metaplastic Carcinoma of the Breast by Large-Scale Transcriptional Profiling: Identification of Genes Potentially Related to Epithelial-Mesenchymal Transition." Oncogene 26:7859-7871.
  52. Cheng, K.-C., Huang, H.-C., Chen, J.-H., Hsu, J.-W., Cheng, H.-C., Ou, C.-H., Yang, W.-B., Chen, S.-T., Wong, C.-H. and Juan, H.-F. * (2007) " Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction" BMC Genomics 8:411.
  53. Huang, T.-C., Huang, H.-C., Chang, C.-C., Chang, H.-Y., Ou, C.-H., Hsu, C.-H., Chen, S.-T. and Juan, H.-F. * (2007) "An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells." FEBS Letters 581:3517-3522.
  54. Leu, J.-H., Chang, C.-C., Wu, J.-L., Hsu, C.-W., Hirono, I. , Aoki, T., Juan, H.-F. , Lo, C.-F., Kou, G.-H. * , Huang H.-C. * (2007) "Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon ." BMC Genomics 8:120.
  55. Fang, Y.-C., Sun, W.-H.*, Wu, L.-C., Huang, H.-D., Juan, H.-F. , Horng, J.-T.* (2006) "RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling." BMC Genomics 7 :317.
  56. Tseng, H.-W., Juan, H.-F. , Huang, H.-C., Lin, J. Y.-C., Sinchaikul, S., Chen , C.-F., Chen, S.-T. * , Wang * , G.-J. (2006) "A systems biology study of lipopolysaccharide-stimulated responses in rat aortic endothelial cell." Proteomics 6 :5915-5928.
  57. Chen, Y.-R., Juan, H.-F. , Huang, H.-C., Huang, H.-H., Lee, Y.-J., Liao, M.-Y., Tseng, C.-W., Lin, L.-L., M.-Y. Chen, J.-Y., Wang, M.-J., J.-H. Chen * , Y.-J. Chen * (2006) "Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells." Journal Proteome Research 5 :2727-2742.
  58. Huang, B., Chu , C.-H., Chen, S.-L., Juan, H.-F. * and Chen, Y.-M. * (2006) "Proteomics Study of Mung Bean Epicotyl Regulated by Brassinosteroid under Chilling Condition." Cellular & Molecular Biology Letters 11 :264-278.
  59. Juan, H.-F. * , Wang, I-H., Huang, T.-C., Li, J.-J., Chen, S.-T., Huang, H.-C. (2006) " Proteomics analysis of a novel compound – cyclic RGD in breast carcinoma cell line MCF-7. " Proteomics 6 :2991-3000. ( Cover Picture )
  60. Lee, T.-Y., Horng, J.-T., Juan, H.-F. , Huang, H.-D., Wu, L.-C., Lin, F.-M., Huang, H.-C (2006) "An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints." Journal of Computational Chemistry 27 :1020-1032.
  61. Horng, J.-T., Lee, T.-Y., Wu, L.-C., Huang, H.-D., Juan, H.-F. , Lin, F.-M. (2005) "MultiProtIdent: Identifying Proteins Using Database Search and Protein-Protein Interactions." Journal Proteome Research 4 :690-697.
  62. Juan, H.-F. * , Chang, S.-C., Huang, H.-C., Chen, S.-T. (2005) "A New Application of Microwave Technology to Proteomics." Proteomics 5 :840-842.
  63. Wu, C.-C., Huang, H.-C., Juan, H.-F. , Chen, S.-T. (2004) " GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data. " Bioinformatics 20 : 3691-3693.
  64. Chen, C.-Y., Oyang, Y.-J., Juan, H.-F. (2004) " Incremental generation of summarized clustering hierarchy for protein family analysis. " Bioinformatics 20 :2586-96.
  65. Juan, H.-F. , Chen, J.-H., Hsu, W.-T., Huang, S.-C., Chen, S.-T., Lin, J. Y. C., Chang, Y.-W. Chiang, C.-Y., Wen, L.-L., Chan, D.-C., Liu, Y.-C., Chen, Y.-J. (2004) "Identification of tumor-associated plasma biomarkers using proteomic techniques: from mouse to human." Proteomics 4 : 2766-2775. ( Cover Picture )
  66. Wu, C.-Y. Jan, J.-T., Ma, H.-H., Kuo, C.-J., Juan, H.-F. , Cheng, Y.-S. E., Hsu, H.-H., Huang, H.-C., Wu, D., Brik, A., Liang, F.-S., Liu, R.-S., Fang , J.-M., Chen, S.-T., Liang , P.-H. and Chi-Huey Wong (2004) "Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus." Proc. Natl. Acad. Sci. U S A 101 : 10012-10017.
  67. Juan, H.-F. , Liu, H.-L., Hsu, J.-P. (2004) "Recent developments in structural proteomics: from protein identifications and structure determinations to protein-protein interactions" Current Proteomics 1 : 183-197. (Invited review paper)
  68. Chang, D. T.-H, Chen, C.-Y., Chung, W.-C., Oyang, Y.-J., Juan, H.-F. , Huang, H.-C. (2004) "ProteMiner-SSM: A web server for efficient analysis of similar protein tertiary substructures" Nucleic Acids Research. 32 : W76-82.
  69. Wu, S.-F., Liu, T.-M., Lin, Y.-C., Sytwu, H.-K., Juan, H.-F. , Chen, S.-T., Shen, K.-L., Hsi, S.-C., Hsieh, S.-L. (2004) "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone-marrow-derived dendritic cells in non-obese diabetic mice: From regulatory mechanism to clinical implication" Journal of Leukocyte Biology 75 : 1-14.
  70. Juan, H.-F. , Lin, J. Y. C., Chang, W. H., Wu, C. Y., Pan, T. L. Tseng, M. J., Khoo, K. H. and Chen, S. T. (2002) "Biomic study of human myloid leukemia cell (HL-60) differentiated to macrophage using DNA array , proteomic, and bioinformatic analytical methods" Electrophoresis 23 : 2490 -2504.
  71. Sinchaikul, S., Sookkheo, B., Topanuruk, S., Juan, H.-F. , Phutrakul, S., and Chen, S.-T. (2002) "The bioinformatics, functional genomics, and proteomics study of Bacillus sp." J. Chromatogr B 771 : 261-287.
  72. Xu, D.-H., Juan, H.-F. , Nohda, M., Ban, T. (2001) “Optimization of AFLP method in wheat and its application to QTL mapping for spike characters” Breeding Research 3: 25.
  73. Juan, H.-F ., Hung, C.-C., Wang, K.-T., Chiou, S.-H.* (1999) "Comparison of three classes of snake neurotoxins by homology modeling and computer simulation graphics." Biochem Biophys Res Commun. 257 : 500-510.

Book and book chapters:

  1. Juan, H.-F. and Huang, H.-C. (2012) Systems Biology: Applications in cancer-related research (World Scientific Publishing, Singapore).
  2. Juan, H.-F. and Huang, H.-C. (2007) "Bioinformatics: Microarray Data Clustering and Functional Classification" in Microarrays (2nd ed): Applications and Data Analysis, ed. Jang B. Rampal (The humana press inc.), pp. 401-414.
  3. 陳水田、曾銘仁、阮雪芬等 (2003) 基因體科學入門, 藝軒. [A Primer of Genome Science, Gibson, G. and Muse, S. V., Sinauer Associates Inc. (2001)]

Courses Information

  Bioinformatics
  Seminar on Systems Biology
  Genomics
 

General Biology

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