National Taiwan University | College of Life Science
 
FACULTY
Director
Professor
Associate Professor
Assistant Professor
>Home >FACULTY> Hsueh-Fen Juan , Professor
Hsueh-Fen Juan , Professor
 
Distinguished Professor

Born in 1969

Ph. D. NationalTaiwanUniversity
Specialty Bioinformatics, Genomic, Proteomics

E-mail : yukijuan@ntu.edu.tw
Laboratory： Life Science Building R1105

TEL 886-2- 33664536

Recent Research Topics
  • Elucidating the response pathways of ectopic ATP synthase by combining proteomics and network biology .
  • Studying protein interaction networks and signal pathways of novel oncoprotein ZNF322A .
  • Integrative omics and network study of miRNA regulation in cancer progression .

Laboratory: Systems Biology Laboratory

Systems Biology Laboratory

　　Systems biology is a new field that focuses on understanding biological processes and their functional activities from a system-wide perspective. With the advent of high-throughput omics technologies and computational methods, systems biology has become a viable approach to improve our knowledge of health and disease. This holistic approach will enable more rapid advances in elucidating biomolecular pathways and identifying targets for drug discovery and disease therapies. To integrate the data generated from omics technologies, there is much academic focus on developing fundamental computational and informatics tools into models of regulatory networks and cell behavior. Classic bench-top experiments are used hand in hand to provide high-throughput data and to validate simulated predictions. Through an iterative process of experimental assays, data analyses and computational simulations, in silico models are refined so as to more closely reflect the biological reality. The main research in our lab is to apply systems biology for drug discovery and investigate the molecular mechanism of the drugs in cancer cells.

　　Targeting tumor tissues is one of the most powerful approaches to accelerate the efficiency of anticancer treatments. We discovered a novel anti-cancer drug for targeting therapy. This finding, described as the first to test possible medical uses of so-called ATP-synthase inhibitors, may lead to new and more effective anti-cancer medications. Additionally, we elucidated the mechanism of anti-cancer novel drugs, sialyltransferase inhibitor, OSU03013 and cRGD. Our findings show their potential to be anticancer drugs and this information presents a valuable in-depth description of their possible impact on cancer therapy.

　　MicroRNAs are short single-stranded non-coding RNA molecules which play a key role in post-transcriptional regulation of mRNAs. A miRNA can affect many downstream targets which in turn form a complicated network. Our lab has characterized the roles of miRNAs in the regulation of cellular networks and revealed that miRNA-regulated network could be used as a novel therapeutic target for cancer as well as other diseases such as neurological and cardiovascular diseases.

Selected Research Publications

Journal Papers:

  1. Chen, K.-P., Hsu, C.-L., Oyang, Y.-J., Huang, H.-C.*, Juan, H.-F.* (2022) "BIC: a database for the transcriptional landscape of bacteria in cancer" Nucleic Acids Research (https://doi.org/10.1093/nar/gkac891).

  2. Hsu, C.-L.#, Yin, C.-F.#, Chang, Y.-W., Fan, Y.-C., Lin, S.-H., Wu, Y.-C., Huang, H.-C.*, Juan, H.-F.* (2022) "LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/2" Cell Death & Disease 13:809.

  3.  Wu, S.-Y., Wu, H.-T., Wang, Y.-C., Chang, C.-J., Shan, Y.-S., Wu, S.-R., Chiu, Y.-C., Hsu, C.-L., Juan, H.-F., Lan, K.-Y., Chu, C.-W., Lee, Y.-R., Lan, S.-H., Liu, H.-S. (2022) "Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo" Autophagy Sep 15:1-19. doi: 10.1080/15548627.2022.2123098.

  4. Li, P.-H., Chen, T.-F., Yu, J.-Y., Shih, S.-H., Su, C.-H., Lin, Y.-H., Tsai, H.-K., Juan, H.-F., Chen, C.-Y., Huang, J.-H. (2022) "pubmedKB: an interactive web server for exploring biomedical entity relations in the biomedical literature" Nucleic Acids Research 50(W1):W616-W622.

  5. Chang, Y.-W., Wang, C.-C, Yin, C.-F., Wu, C.-H., Huang, H.-C.*, Juan, H.-F.* (2022) "Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation" Molecular & Cellular Proteomics 21(6):100237.

  6. Li, A., Chen, J.-Y., Hsu, C.-L., Oyang, Y.-J., Huang, H.-C.*, Juan, H.-F.* (2022) "A single-cell network-based drug repositioning strategy for post-COVID-19 pulmonary fibrosis" Pharmaceutics 14:971.

  7. Lee, R. K.-L., Li, T.-N., Chang, S.-Y., Chao, T.-L., Kuo, C.-H., Pan, M. Y.-C., Chiou, Y.-T., Liao, K.-J., Yang, Y., Wu, Y.-H., Huang, C.-H., Juan, H.-F., Hsieh, H.-P., Wang, L. H.-C. (2022) "Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2" International Journal of Molecular Sciences 23:4050.

  8. Yin, C.-F.#, Chang, Y.-W.#, Huang, H.-C.*, Juan, H.-F.* (2022) "Targeting protein interaction networks in mitochondria dynamics for cancer therapy" Drug Discovery Today 27(4): 1077-1087.

  9. Ko, K.-Y., Chen, C.-Y., Juan, H.-F.* and Huang, H.-C.* (2022) "Phylotranscriptomic patterns of network stochasticity and pathway dynamics during embryogenesis" Bioinformatics 38(3):763-769.

  10. Chang, C.-S.#,, Yu, W.-H.#,, Ruan, J.-W., Huang, C.-T., Lin, C.-M., Tsai, Y.-T., Lin, I-J., Lai, C.-Y., Chang, C.-W., Chuang, T.-H., Lin, W.-J., Tan, T.-H., Huang, H.-C., Juan, H.-F., Kao, C.-Y.* (2022) "Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice" iScience 25(2):103738.

  11. Yu, P.-C.#, Huang, C.-H.#, Kuo, C.-J., Liang, P.-H., Wang, L.H.-C., Pan, M. Y.-C., Chang, S.-Y. Chao, T.-L., Ieong, S., Fang, J.-T., Huang, H.-C.*, Juan, H.-F.* (2022) "Drug repurposing for the identification of compounds with anti-SARS-CoV-2 capability via multiple targets" Pharmaceutics 14:176.

  12. Hsieh, C.-H.#, Yeh, H.-N.#, Huang, C.-T., Wang, W.-H., Hsu, W.-M., Huang, H.-C.*, Juan, H.-F.* (2022) "BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10" Pharmaceuticals 15:37.

  13. Yu, W.-H., Hsu, C.-L., Lin, C.-C., Oyang, Y.-J., Juan, H.-F.* and Huang, H.-C.* (2021) "Stratification of lncRNA modulation networks in breast cancer" BMC Medical Genomics 14:300.

  14. Li, A., Yu, W.-H., Hsu, C.-L., Huang, H.-C.*, Juan, H.-F.* (2021) "Modular signature of long non-coding RNA association networks as a prognostic biomarker in lung cancer" BMC Medical Genomics 14:290.

  15. Chang, C.-S., Liao, Y.-C., Huang, C.-T., Lin, C.-M., Cheung, C. H. Y., Ruan, J.-W., Yu, W.-H., Tsai, Y.-T., Lin, I-J., Huang, C.-H., Liou, J.-S., Chou, Y.-H., Chien, H.-J., Chuang, H.-L., Juan, H.-F., Huang, H.-C., Chan, H.-L., Liao, Y.-C., Tang, S.-C., Su, Y.-W., Tan, T.-H., Baumler, A. J., Kao, C.-Y.* (2021)"Discovery of a novel microbiota member that ameliorates dss-induced colitis in gut barrier enhanced Dusp6-deficient mice" Cell Reports 37:110016.

  16. Tu, Y.-H., Juan, H.-F.* and Huang, H.-C.* (2021) "Identification of cell states using super-enhancer RNA" BMC Genomics 22:787.

  17.  Lee, K.-H., Chang, Y.-C., Chen, T.-F., Juan, H.-F., Tsai, H.-K., Chen, C.-Y. (2021) "Connecting MHC-I-binding motifs with HLA alleles via deep learning" Communications Biology 4:1194.

  18.  Li, A., Huang, H.-T., Huang, H.-C.*, Juan, H.-F.* (2021) "LncTx: A network-based method to repurpose drugs acting on the survival-related lncRNAs in lung cancer" Computational and Structural Biotechnology Journal 19:3990-4002.

  19.  Lee, T.-T., Chen, P.-L., Su, M. P., Li, J.-C., Chang, Y.-W., Liu, R-W, Juan, H.-F, Yang, J.-M., Chan, S.-P., Tsai, Y.-C., von Stockum, S., Ziviani, E., Kamikouchi, A., Wang, H.-D., Chen, C.-H. (2021) "Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila" Aging Cell 20(6):e13379.

  20.  Wang, W.-H., Chen, S.-K., Huang, H.-C.*, Juan, H.-F.* (2021) "Proteomic analysis reveals metformin suppresses PSMD2, STIP1 and CAP1 for anti-gastric cancer AGS cell proliferation and migration" ACS Omega 6(22):14208-14219.

  21.  Peng, C., Li, Y,.-H. Yu, C.-W., Cheng, J.-H., Liu, J.-R., Hsu, J.-L., Hsin, L.-W., Huang, C.-T., Juan, H.-F., Chern, J.-W., Cheng, Y.-S. (2021) "Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity" Bioorganic Chemistry 110:104813.

  22. Chen, T.-F., Chang, Y.-C., Hsiao, Y., Lee, K.-H., Hsiao, Y.-C., Lin, Y.-H., Tu, Y.-C. E., Huang, H.-C., Chen, C.-Y.*, Juan, H.-F.* (2021) "DockCoV2: a drug database against SARS-CoV-2" Nucleic Acids Research 49(D1):D1152-D1159.

  23. Huang, C.-T., Chao, T.-L., Kao, H.-C., Pang, Y.-H., Lee, W.-H., Hsieh, C.-H., Chang, S.-Y.*, Huang, H.-C.*, Juan, H.-F.* (2020) "Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19" Heliyon 6(12):e05646 (Cell Press).

  24.  Chang, Y.-W., Hsu, C.-L., Tang, C.-W., Chen, X.-J., Huang, H.-C.*, Juan, H.-F.* (2020) "Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network" Molecular and Cellular Proteomics 19(11):1805-1825.

  25.  Wu, A. Y.-T., Sun, Y.-C., Chen, Y.-J., Chou, S. T.-Y., Guo, V., Chien, J. C.-Y., Ko, J. J.-S., Yang, A. L., Huang, H.-C., Chuang, J.-C., Wu, S., Ho, M.-R., Ericsson, M., Lin, W.-W., Cheung, C. H. Y., Juan, H.-F., Ueda, K., Chen Y., Lai C. P.-K. (2020) "Multi-resolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism" Advanced Science 7: 2001467.

  26.  Cheung, H. Y. C., Hsu, C.-L., Lin, T.-Y., Chen, W.-T., Wang, Y.-C., Huang, H.-C.*, Juan, H.-F.* (2020) "ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer" Journal of Biomedical Science 27(1):75.

  27.  Wang, W.-H., Hsu, C.-L., Huang, H.-C.*, Juan, H.-F.* (2020) "Quantitative phosphoproteomics reveals cell alignment and mitochondrial length change under cyclic stretching in lung cells" International Journal of Molecular Sciences 21(11):4074.

  28.  Yin, C.-F., Kao, S.-C., Hsu, C.-L., Cheung, C. H.Y., Chang, Y.-W., Huang, H.-C.*, Juan, H.-F.* (2020) "Phosphoproteome analysis reveals dynamic heat shock protein 27 phosphorylation in tanshinone IIA-induced cell death" Journal of Proteome Research 19(4):1620-1634.

  29. Lee, P.-C. Chen, S.-T., Kuo, T.-C., Lin, T.-C., Lin, M.-C., Huang, J., Hung, J.-S., Hsu, C.-L., Juan, H.-F., Lee, P.-H., and Huang, M.-C. (2020) "C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer" Oncogene 39(13):2724-2740.

  30. Lee, W.-H., Chen, K.-P., Wang, K., Huang, H.-C.*, Juan, H.-F.* (2020) "Characterizing the cancer-associated microbiome with small RNA sequencing data" Biochemical and Biophysical Research Communications 522:776-782.

  31. Chang, H.-C., Huang, H.-C., Juan, H.-F.*, Hsu, C.-L* (2019) "Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation" BMC Genomics 20(Suppl 10):896.
  32. Hsieh, C.-H., Cheung, C. H. Y., Liu, Y.-L., Hou, C.-L., Hsu, C.-L., Huang, C.-T., Yang, T.-S., Chen, S.-F., Chen, C.-N., Hsu, W.-M.*, Huang, H.-C.*, Juan, H.-F.* (2019) “Quantitative proteomics of Th-MYCN transgenic mice reveals aurora kinase inhibitor altered metabolic pathways and enhanced ACADM to suppress neuroblastoma progression” Journal of Proteome Research 18(11):3850-3866.
  33. Cheung, H. Y. C., Hsu, C.-L., Tsuei, C.-Y., Kuo, T.-T., Huang, C.-T., Hsu, W.-M., Chung, Y.-H., Wu, H.-Y., Hsu, C.-C., Huang, H.-C.*, Juan, H.-F.* (2019) “Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy” Cell Death & Disease 10:786.
  34. Wu, P.-Y., Yu, I-S., Lin, Y.-C., Chang, Y.-T., Chen, C.-C., Lin, K.-H., Tseng, T.-H., Kargren, M., Tai, Y.-L., Shen, T.-L., Liu, Y.-L., Wang, B.-J., Chang, C.-H., Chen, W.-M., Juan, H.-F., Huang, S.-F., Chan, Y.-Y., Liao, Y.-F., Hsu, W.-M., Lee, H. (2019) “Activation of aryl hydrocarbon receptor by kynurenine impairs progression and metastasis of neuroblastoma” Cancer Research 79(21):5550-5562.
  35. Huang, C.-T., Hsieh, C.-H., Lee, W.-C., Liu, Y.-L., Yang, T.-S., Hsu, W.-M., Oyang, Y.-J., Huang, H.-C.*, Juan, H.-F.* (2019) “Therapeutic targeting of non-oncogene dependencies in high-risk neuroblastoma” Clinical Cancer Research 25(13):4063-4078.
  36. Huang, C.-T., Hsieh, C.-H., Oyang, Y.-J., Huang, H.-C.*, Juan, H.-F.* (2018) "A large-scale gene expression intensity-based similarity metric for drug repositioning" iScience 7: 40-52. (Cell Press)
  37. Yang, T.-W., Sahu, D., Chang, Y.-W., Hsu, C.-L., Hsieh, C.-H., Huang, H.-C.*, Juan, H.-F.* (2019) “RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression” Journal of Proteome Research 18: 406–416.
  38. Chang, J.-Y., Yu, W.-H., Juan, H.-F.*, Huang, H.-C.* (2018) "Dynamics of alternative polyadenylation in human preimplantation embryos" Biochemical and Biophysical Research Communications 504(4):727-733.
  39. Huang, C.-T., Hsieh, C.-H., Oyang, Y.-J., Huang, H.-C.*, Juan, H.-F.* (2018) "A large-scale gene expression intensity-based similarity metric for drug repositioning" iScience 7: 40-52. (Cell Press)
  40. Lin, M.-C., Chien, P.-H., Wu, H.-Y., Chen, S.-T., Juan, H.-F., Lou, P.-J.*, Huang, M.-C.* (2018) "C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer" Oncogene 37:5780-5793.
  41. Sahu, D., Ho, S.-Y., Juan, H.-F.*, Huang, H.-C.* (2018) "High-risk, expression-based prognostic long noncoding RNA signature in neuroblastoma" JNCI Cancer Spectrum 2(2): pky015.
  42. Cheng, A.-N., Fan, C.-C., Lo, Y.-K., Kuo, C.-L., Wang, H.-C., Lien, I-H., Lin, S.-Y., Chen, C.-H., Jiang, S. S., Chang, I-S., Juan, H.-F., Lyu, P.-C., Lee, A Y.-L.* (2017) "Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer" Scientific Reports 7: 17024.
  43. Cheung, H. Y. C., Hsu, C.-L., Chen, K.-P., Chong, S.-T., Huang, H.-C.*, Juan, H.-F.* (2017) "MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach" Scientific Reports 7(1):13302.
  44. Hsu, C.-L., Wang, J.-K., Lu, P.-C., Huang, H.-C.*, and Juan, H.-F.* (2017) "DynaPho: a web platform for inferring the dynamics of time-series phosphoproteomics" Bioinformatics 33(22):3664-3666.
  45. Hua, K.-T., Liu, Y.-F., Hsu, C.-L., Cheng, T.-Y., Yang, C.-Y., Chang, J.-S., Lee, W.-J., Hsiao, M., Juan, H.-F., Chien, M.-H.*, Yang, S.-F.* (2017) "3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma" Scientific Reports 7:4466.
  46. Cheung, C. H.-Y., Juan, H.-F.*. (2017) "Quantitative Proteomics in Lung Cancer" Journal of Biomedical Science 24:37.
  47. Liao, S.-Y., Chiang, C.-W., Hsu, C.-H., Jen, J., Juan, H.-F., Lai, W.-W., and Wang, Y.-C.* (2017) "CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression" Oncogene 36(41):5722-5733.
  48. Lin, T-.C., Chen, S.-T., Huang, M.-C., Huang, J., Hsu, C.-L., Juan, H.-F., Lin, H.-H., Chen, C.-H.* (2017) "GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity" Oncotarget 8(26):42588-42601.
  49. Lin, M.-C., Lin, J.-J., Hsu, C.-L., Juan, H.-F., Lou, P.-J.*, Huang, M.-C.* (2017) "GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness" Oncogene 36(30):4380.
  50. Chang, H.-H., Liu, Y.-L., Lu, M.-Y., Jou, S.-T., Yang, Y.-L., Lin, D.-T., Lin, K.-H., Tzen, K.-Y. Yen, R.-F., Lu, C.-C., Liu, C.-J., Peng, S. S.-F., Jeng, Y.-M., Huang, S.-F., Lee, H., Juan, H.-F., Huang, M.-C., Liao, Y.-F., Lee, Y.-L.*, Hsu, W.-M.* (2017) "A multidisciplinary team care approach to improving outcomes in pediatric patients with high-risk neuroblastoma" Oncotarget 8(3):4360-72.
  51. Wang, Y.-T., Chiang, H.-H., Huang, Y.-S., Hsu, C.-L., Yang, P.-J., Juan, H.-F., Yang, W.-S.* (2016) "A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA" Cell Death and Disease 7(11):e2458.
  52. Wu, C.-H., Hsu, C.-L., Lu, P.-C., Lin, W.-C., Juan, H.-F.*, Huang, H.-C.* (2016) "Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules" Scientific Reports 6:35939.
  53. Sahu, D., Hsu, C.-L., Lin, C.-C., Yang, T.-W., Hsu, W.-M., Ho, S.-Y., Juan, H.-F.*, Huang, H.-C.* (2016) "Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma" Oncotarget 9(36): 58022-37.
  54. Hsu, C.-L., Chang, H.-Y., Chang, J.-Y., Hsu, W.-M., Huang, H.-C.* and Juan, H.-F.* (2016) "Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data" Oncotarget 7(24):36293-310.
  55. Lin, M.-T., Wang, C.-Y., Xie, H.-J., Cheung, C. H. Y., Hsieh, C.-H., Juan, H.-F., Chen, B.-S., C. Lin* (2016) "Novel utilization of terminators in the design of biologically adjustable synthetic filters" ACS Synthetic Biology 5(5):365-74.
  56. Jen, J., Lin, L.-L., Chen, H.-T., Liao, S.-Y., Lo, F.-Y., Tang, Y.-A., Hsu, H.-S., Salgia, R., Hsu, C.-L., Huang, H.-C., Juan, H.-F.*, Wang, Y.-C.* (2016) "Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer" Oncogene 35(18):2357-69.
  57. Liu, S.-Y., Shun, C.-T., Hung, K.-Y., Juan, H.-F., Hsu, C.-L., Huang, M.-C.*, Lai, I-R.* (2016) "Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation" Oncotarget 7(10):11251-62.
  58. Klionsky, D.-J., et al. (2016) "Guidelines for the use and interpretation of assays for monitoring autophagy" Autophagy 12(1):1-222.
  59. Hu, C.-W., Hsu, C.-L., Wang, Y.-C., Ishihama, Y., Ku, W-C., Huang, H.-C.* and Juan, H.-F.* (2015) "Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin" Molecular & Cellular Proteomics 14(12):3284-98.
  60. Hsu, C.-L., Juan, H.-F.*, and Huang, H.-C.* (2015) "Characterization and functional analysis of differential coexpression networks" Scientific Reports5:13295.
  61. Lin, L.-L., Hsu, C.-L., Hu, C.-W., Ko, S.-Y., Hsieh, H.-L., Huang, H.-C.*, Juan, H.-F.* (2015) "Integrating phosphoproteomics and bioinformatics to study brassinosteroid-regulated phosphorylation dynamics in Arabidopsis"BMC Genomics 16:533. (Highly accessed)
  62. Lin, L.-L., Huang, H.-C.*, Juan, H.-F.* (2015) "Circadian systems biology in metazoa" Briefings in Bioinformatics (Mar 10 online)
  63. Huang, M.-J., Hu, R.-H., Chou, C.-H., Hsu, C.-L., Liu, Y.-W., Huang, J., Hung, J.-S., Lai, I-R., Juan, H.-F., Yu, S.-L., Wu, Y.-M.* and Huang, M.-C.*(2015) "Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling" Oncotarget6(8):5650-65.
  64. Lee, A. Y.-L.*, Chiu, Y.-C., Fang, W.-C., Cheng, C.-W., Kuo, C.-Y., Juan, H.-F., Wu, S.-H.* and Kao, T.-Y.* (2015) "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex" Cell Death & Disease 6:e1642.
  65. Lin, L.-L., Hsia, C.-R., Hsu, C.-L., Huang, H.-C.* and Juan, H.-F.* (2015) "Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells" BMC Genomics 16(1):41.
  66. Chang, H.-Y., Li, M.-H., Huang, T.-C., Hsu, C.-L., Tsai, S.-R., Lee, S.-C.*, Huang, H.-C.* and Juan, H.-F.* (2015) "Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells" Journal of Proteome Research 14(2):1250-62.
  67. Chang, H.-Y., Huang, T.-C., Chen, N.-N., Huang, H.-C.* and Juan, H.-F.*(2014) "Combination therapy targeting ectopic ATP synthase and 26s proteasome induces ER stress in breast cancer cells" Cell Death & Disease5:e1540.
  68. Chen, C.-Y., Ho, A., Huang, H.-Y., Juan, H.-F.* and Huang, H.-C.* (2014) "Dissecting the human protein-protein interaction network via phylogenetic decomposition" Scientific Reports 4:7153.
  69. Huang, C.-T., Oyang, Y.-J., Huang, H.-C.* and Juan, H.-F.* (2014) "MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma" Scientific Reports 4:6495.
  70. Lin, L.-L., Huang, H.-C.*, Juan, H.-F.* (2014) "Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches" Drug Discovery Today 19(9):1402-1409.
  71. Yang, K.-C., Hsu, C.-L., Lin, C.-C., Juan, H.-F.* and Huang, H.-C.* (2014) "Mirin: identifying microRNA regulatory modules in protein-protein interaction networks" Bioinformatics 30(17):2527-2528.
  72. Chen. C.-M., Chen, I.-C., Huang, Y.-C., Juan, H.-F., Chen, Y.-L., Chen, Y.-C., Lin, C.-H., Lee, L.-C., Lee, C.-M., Lee-Chen, G.-J., Lai, Y.-J., and Wu, Y.-R. (2014) "FBXO7 Y52C polymorphism as a potential protective factor in parkinson's disease" PLoS ONE 9(7):e101392.
  73. Hsieh, L.-C., Chen, J.-W., Wang, L.-Y., Tsang, Y.-M., Shueng, P.-W., Liao, L.-J., Lo, W.-C., Lin, Y.-C., Tseng, C.-F., Kuo, Y.-S., Jhuang, J.-Y., Tien, H.-J., Juan, H.-F., and Hsieh, C.-H. (2014) "Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging" PLoS ONE 9(3):e92561.
  74. Huang, W.-J., Tang, Y.-A., Chen, M.-Y, Wang, Y.-J., Hu, F.-H., Wang, T.-W., Chao, S.-W. Chiu, H.-W., Yeh, Y.-L., Chang, H.-Y., Juan, H.-F., Lin, P.*, and Wang, Y.-C.* (2014) "A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies" Cancer Letter 346(1):84-93.
  75. Wu, P.-Y., Liao, Y.-F., Juan, H.-F., Huang, H.-C., Wang, B.-J., Lu, Y.-L., Yu, I-S., Shih, Y.-Y., Jeng, Y.-M., Hsu, W.-M.*, and Lee, H.* (2014) "Aryl hydrocarbon receptor downregulates mycn expression and promotes cell differentiation of neuroblastoma" PLoS ONE 9(2): e88795.
  76. Hu, C.-W., Tseng, C.-W., Chien, C.-W., Huang, H.-C., Ku, W.-C., Lee, S.-J.*, Chen, Y.-J.* and Juan, H.-F.* (2013) "Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development" Journal of Proteome Research 12(9):3993-4004.
  77. Wu, Y.-H., Hu, C.-W., Chien, C.-W., Chen, Y.-J., Huang, H.-C.* and Juan, H.-F.* (2013) "Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin" PLoS ONE 8(8):e70642.
  78. Lin, L.-L., Wu, C.-C., Huang, H.-C.*, Chen, H.-J. Hsieh, H.-L.*, and Juan, H.-F.* (2013) "Identification of microRNA 395a in 24-epibrassinolide-regulated root growth of Arabidopsis thaliana using microRNA arrays" International Journal of Molecular Sciences 14:14270-14286.
  79. Lin, C.-C., Lee, C.-H., Fuh, C.-S., Juan, H.-F.* and Huang, H.-C.* (2013) "Link clustering reveals structural characteristics and biological contexts in signed molecular networks" PLoS ONE 8(6): e67089.
  80. Lee, C.-H., Kuo, W.-H., Lin, C.-C., Oyang, Y.-J., Huang, H.-C.* and Juan, H.-F.* (2013) "MicroRNA-regulated protein-protein interaction networks and their functions in breast cancer" International Journal of Molecular Sciences 14:11560-11606.
  81. Liaw, H.-H., Lin, C.-C., Juan, H.-F.* and Huang, H.-C.* (2013) "Differential microRNA regulation correlates with alternative polyadenylation pattern between breast cancer and normal cells" PLoS ONE 8(2): e56958.
  82. Chang, H.-Y., Shih, M.-H., Huang, H.-C., Tsai, S.-R., Juan, H.-F.*, Lee, S.-C.* (2013) "Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells" PLoS ONE 8(1): e54117. (Featured on PLoS Blog)
  83. Fu, S.-C., Huang, H.-C., Horton, P.* and Juan, H.-F.* (2013) "ValidNESs: a database of validated leucine-rich nuclear export signals" Nucleic Acids Research 41(D1):D338-D343.
  84. Chen, C.-Y., Chen, S.-T., Juan, H.-F.* and Huang, H.-C.* (2012) "Lengthening of 3'UTR increases morphological complexity in animal evolution" Bioinformatics 28(24):3178-3181.
  85. Lu, K.-Y., Tao, S.-C., Yang, T.-C., Ho, Y.-H., Lee, C.-H., Lin, C.-C., Juan, H.-F., Huang, H.-C. , Yang, C.-Y., M,-S, Chen, H. Zhu*, and C.-S. Chen* (2012) "Profiling lipid-protein interactions using non-quenched fluorescent liposomal nanovesicles and proteome microarrays" Molecular & Cellular Proteomics 11(11):1177-1190.
  86. Hu, C.-W., Lin, M.-H., Huang, H.-C., Ku, W.-C., Yi, T.-H., Tsai, C.-F., Chen, Y.-J., Sugiyama, N., Ishihama, Y.*, Juan, H.-F.*, and Wu, S.-H.* (2012) "Phosphoproteomic analysis of Rhodopseudomonas palustris reveals the role of pyruvate phosphate dikinase phosphorylation in lipid production" Journal of Proteome Research 11:5362-5375.
  87. Lin, L.-L., Wang, Y.-H., Lai, C.-Y., Chau, C.-L., Su, G.-C., Yang, C.-Y., Lou, S.-Y., Chen, S.-K., Hsu, K.-H., Lai, Y.-L., Wu, W.-M., Huang, J.-L., Liao, C.-H. and Juan, H.-F.* (2012) "Systems biology of meridians, acupoints, and Chinese herbs in disease" Evidence-Based Complementary and Alternative Medicine 2012:372670.
  88. Lin, L.-L., Huang, H.-C., Ogihara, S., Wang, J.-T., Wu, M.-C., McNeil, P. L.*, Chen, C.-N.* and Juan, H.-F.* (2012) "Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation" International Journal of Molecular Sciences 13:10176-10192.
  89. Lin, L.-L., Huang, H.-C.*, and Juan, H.-F.* (2012) "Revealing the molecular mechanism of gastric cancer marker Annexin A4 in cancer cell proliferation using exon arrays" PLoS ONE 7(9):e44615.
  90. Chang, H.-Y., Huang, H.-C., Huang, T.-C., Yang, P.-C.*, Wang, Y.-C.*, and Juan, H.-F.* (2012) "Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response" Cancer Research 72(18):4696-4706.
  91. Shih, Y.-Y., Nakagawara, A., Lee, H., Juan, H.-F., Jeng, Y.-M., Lin, D.-T., Yang, Y.-L., Tsay, Y.-G., Huang, M.-C., Pan, C.-Y., Hsu, W.-M., Liao, Y.-F.(2012) Calreticulin mediates nerve growth factor-induced neuronal differentiation. Journal of Molecular Neuroscience, 47 (3), pp. 571-581.
  92. Lin, L.-L., Huang, H.-C., Juan, H.-F.(2012) Discovery of biomarkers for gastric cancer: A proteomics approach (2012) Journal of Proteomics, 75 (11), pp. 3081-3097.
  93. Chang, M.-W., Lo, J.-M., Juan, H.-F., Chang, H.-Y., Chuang, C.-Y. (2012) Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells. PLoS ONE, 7 (5), art. no. e37935, .
  94. Tseng, C.-W., Huang, H.-C., Shih, A.C.-C., Chang, Y.-Y., Hsu, C.-C., Chang, J.-Y., Li, W.-H., Juan, H.-F.(2012) Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D. International Journal of Molecular Sciences, 13 (5), pp. 6352-6369.
  95. Lin, C.-C., Chen, Y.-J., Chen, C.-Y., Oyang, Y.-J., Juan, H.-F., Huang, H.-C.(2012) Crosstalk between transcription factors and microRNAs in human protein interaction network. BMC Systems Biology, 6, art. no. 18, .
  96. Hu, C.-W., Chang, Y.-L., Chen, S.J., Kuo-Huang, L.-L., Liao, J.C., Huang, H.-C., Juan, H.-F.(2011) Revealing the functions of the transketolase enzyme isoforms in rhodopseudomonas palustris using a systems biology approach. PLoS ONE, 6 (12), art. no. e28329, .
  97. Chen, S.-T., Jeng, Y.-M., Chang, C.-C., Chang, H.-H., Huang, M.-C., Juan, H.-F., Hsu, C.-H., Lee, H., Liao, Y.-F., Lee, Y.-L., Hsu, W.-M., Lai, H.-S.(2011) Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma Cancer Science, 102 (12), pp. 2191-2198.
  98. Huang, T.-C., Chang, H.-Y., Chen, C.-Y., Wu, P.-Y., Lee, H., Liao, Y.-F., Hsu, W.-M., Huang, H.-C., Juan, H.-F.(2011) Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR FEBS Letters, 585 (22), pp. 3582-3586.
  99. Tsai, S.-R., Huang, T.-C., Liang, C.-M., Chang, H.-Y., Chang, Y.-T., Huang, H.-C., Juan, H.-F., Lee, S.-C.(2011) The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli. Applied Physics Letters, 99 (16), art. no. 163704, .
  100. Chen, C.-M., Lin, C.-H., Juan, H.-F., Hu, F.-J., Hsiao, Y.-C., Chang, H.-Y., Chao, C.-Y., Chen, I.-C., Lee, L.-C., Wang, T.-W., Chen, Y.-T., Chen, Y.-T., Lee-Chen, G.-J., Wu, Y.-R.(2011) ATP13A2 variability in Taiwanese Parkinson's disease American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156 (6), pp. 720-729.
  101. Lee, C.-H., Huang, H.-C., Juan, H.-F.(2011) Reviewing ligand-based rational drug design: The search for an ATP synthase inhibitor. International Journal of Molecular Sciences, 12 (8), pp. 5304-5318.
  102. Tseng, C.-W., Lin, C.-C., Chen, C.-N., Huang, H.-C., Juan, H.-F.(2011) Integrative network analysis reveals active microRNAs and their functions in gastric cancer. BMC Systems Biology, 5, art. no. 99,
  103. Tseng, C.-W., Yang, J.-C., Chen, C.-N., Huang, H.-C., Chuang, K.-N., Lin, C.-C., Lai, H.-S., Lee, P.-H., Chang, K.-J., Juan, H.-F.(2011) Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker Proteomics, 11 (12), pp. 2423-2439.
  104. Juan, H.-F., Hsu, J.-W., Huang, H.-C., Chen, S.-T., Wong, C.-H.(2011) Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation. Evidence-based Complementary and Alternative Medicine, 2011, art. no. 358717, .
  105. Chen, C-Y, Chen, S.-T., Fuh, C.-S. Juan, H.-F.*, Huang H.-C.* (2011) "Coregulation of Transcription Factors and microRNAs in Transcriptional Regulatory Network" BMC Bioinformatics 12 (Suppl 1):S41.
  106. Chen, J.-Y., Huang, S.-M., Tang, Y.-A., Juan, H.-F., Wu, L.-W., Sun, Y.-C., Wang, S.-C., Wu, K. W., Balraj, G., Chang, T.-T., Li, W.-S.*, Cheng, H.-C.*, Wang, Y.-C.* (2011) "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis" Cancer Research 71:473-483.
  107. Lin, C.-C., Hsiang, J.-T., Wu, C.-Y., Oyang, Y.-J., Juan, H.-F.* ,Huang H.-C. * (2010) "Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy" BMC Systems Biology 4:138.
  108. Chang, H.-H., Lee, H.-Y., Hu, M.-K., Tsao, P.-N., Juan, H.-F., Huang, M.-C., Shih, Y.-Y., Wang, B.-J., Jeng, Y.-M., Chang, C., Huang, S.-F., Y.-G. Tsay, Hsieh, F.-J., Lin, K.-H. * , Hsu, W.-M. * , and Liao, Y.-F * . (2010) "Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma" Clinical Cancer Research 16:4411-4420.
  109. Hsu, J.-W., Huang H.-C. , Chen, S.-T., Wong, C.-H. , Juan, H.-F.* (2009) "Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation" Evidence-Based Complementary and Alternative Medicine ; doi: 10.1093/ecam/nep107
  110. Hwang Y.-C., Lin C.-C., Chang J.-Y., Mori H., Juan, H.-F.* , Huang H.-C. * (2009) "Predicting essential genes based on network and sequence analysis" Molecular BioSystems 5:1672–1678.
  111. Lin, C.-C., Juan, H.-F., Hsiang, J.-T., Hwang, Y.-C., Mori, H. * , Huang, H.-C. * (2009) "Essential core of protein-protein interaction network in Escherichia coli " Journal of Proteome Research 8(4):1925-1931.
  112. Chang, Y.-M., Juan, H.-F., Lee, T.-Y., Chang, Y.-Y., Yeh, Y.-M., Li, W.-H. * , Shih, A. C.-C. (2008) "Prediction of human miRNAs using tissue-selective motifs in 3' UTRs" Proc. Natl. Acad. Sci. U S A 105, 17061-17066. ( Highlighted in Nature Biotechnology and in Science-Business eXchange (SciBX) )
  113. Fang, Y.-C., Huang, H.-C. , Chen, H.-H. and Juan, H.-F.* (2008) "TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining" BMC Complementary and Alternative Medicine 8:58.
  114. W.-M. Hsu, H.-Y. Lee, Juan, H.-F., Y.-Y. Shih, B-J. Wang, C.-Y. Pan, Y.-M. Jeng, H.-H. Chang, M.-Y. Lu, K.-H. Lin, H.-S. Lai, W.-J. Chen, Y.-G. Tsay * , Y.-F. Liao * , F.-J. Hsieh * (2008) "Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis" Clinical Cancer Research 14:6237-6245.
  115. Hsu, C.-W., Juan, H.-F.* , Huang, H.-C. * (2008) "Characterization of microRNA-Regulated Protein-Protein Interaction Network" Proteomics 8:1975-1979.
  116. Lin, L.-L., C.-N. Chen*, Lin, W.-C., Lee, P.-H., Chang, K.-J., Lai, Y.-P., Wang, J.-T., Juan, H.-F.* (2008) "Annexin A4: A novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach " Proteomics: clinical applications 2:619-634.
  117. Chen, S.-T., Pan, T.-L., Juan, H.-F., Chen, T.-Y., Lin, Y.-S., Huang, C.-M. * (2008) "Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome and Extracellular Matrix" Journal of Proteome Research 7:1379-1387.
  118. Huang, T.-C., Chang, H.-Y., Hsu, C.-H., Kuo, W.-H., Chang, K.-J., Juan, H.-F.* (2008) "Targeting Therapy on Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B" Journal of Proteome Research 7:1433-1444. ( Science Daily news & American Chemical Society weekly news )
  119. Chen, H.-W., Huang, H.-C., Lin, Y.-S., Chang, K.-J., Kuo, W.-H., Hwa, H.-L., Hsieh, F.-J. * , Juan, H.-F.* (2008) "Comparison and Identification of Estrogen-Receptor Related Gene Expression Profiles in Breast Cancer of Different Ethnic Origins" Breast Cancer: Basic and Clinical Research 1:35-49.
  120. Tan, Y-H., Lee, K.-H., Sun, Y.-C., Juan, H.-F.* , Y.-C. Wang * (2008) "Cytotoxicity and proteomics analyses of OSU 03013 in lung cancer" Clinical Cancer Research 14:1823-1830.
  121. Fang, Y.-C., Huang, H.-C. * , Juan, H.-F.* (2008) "MeInfoText: Associated Gene Methylation and Cancer Information from Text Mining" BMC Bioinformatics 9:22.
  122. Huang, B., Ni, K.-C., Chen, S.-L., Juan, H.-F.* , Chen Y.-M. * (2008) "Elucidating the Growth Regulation of Brassinosteroids in Mung Bean Epicotyls using a Proteomics Approach" Proteomics Research Journal 1: 1-18.
  123. Lien, H.-C., Hsiao, Y.-H., Lin, Y.-S., Yao , Y.-T., Juan, H.-F., Kuo, W.-H., Hung, M.-C., Chang, K.-J., Hsieh, F.-J. * (2007) "Molecular Signatures of Metaplastic Carcinoma of the Breast by Large-Scale Transcriptional Profiling: Identification of Genes Potentially Related to Epithelial-Mesenchymal Transition." Oncogene 26:7859-7871.
  124. Cheng, K.-C., Huang, H.-C., Chen, J.-H., Hsu, J.-W., Cheng, H.-C., Ou, C.-H., Yang, W.-B., Chen, S.-T., Wong, C.-H. and Juan, H.-F.* (2007) " Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction" BMC Genomics 8:411.
  125. Huang, T.-C., Huang, H.-C., Chang, C.-C., Chang, H.-Y., Ou, C.-H., Hsu, C.-H., Chen, S.-T. and Juan, H.-F.* (2007) "An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells." FEBS Letters 581:3517-3522.
  126. Leu, J.-H., Chang, C.-C., Wu, J.-L., Hsu, C.-W., Hirono, I. , Aoki, T., Juan, H.-F., Lo, C.-F., Kou, G.-H. * , Huang H.-C. * (2007) "Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon ." BMC Genomics 8:120.
  127. Fang, Y.-C., Sun, W.-H.*, Wu, L.-C., Huang, H.-D., Juan, H.-F., Horng, J.-T.* (2006) "RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling." BMC Genomics 7 :317.
  128. Tseng, H.-W., Juan, H.-F., Huang, H.-C., Lin, J. Y.-C., Sinchaikul, S., Chen , C.-F., Chen, S.-T. * , Wang * , G.-J. (2006) "A systems biology study of lipopolysaccharide-stimulated responses in rat aortic endothelial cell." Proteomics 6 :5915-5928.
  129. Chen, Y.-R., Juan, H.-F., Huang, H.-C., Huang, H.-H., Lee, Y.-J., Liao, M.-Y., Tseng, C.-W., Lin, L.-L., M.-Y. Chen, J.-Y., Wang, M.-J., J.-H. Chen * , Y.-J. Chen * (2006) "Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells." Journal Proteome Research 5 :2727-2742.
  130. Huang, B., Chu , C.-H., Chen, S.-L., Juan, H.-F.* and Chen, Y.-M. * (2006) "Proteomics Study of Mung Bean Epicotyl Regulated by Brassinosteroid under Chilling Condition." Cellular & Molecular Biology Letters 11 :264-278.
  131. Juan, H.-F.* , Wang, I-H., Huang, T.-C., Li, J.-J., Chen, S.-T., Huang, H.-C. (2006) " Proteomics analysis of a novel compound – cyclic RGD in breast carcinoma cell line MCF-7. " Proteomics 6 :2991-3000. ( Cover Picture )
  132. Lee, T.-Y., Horng, J.-T., Juan, H.-F., Huang, H.-D., Wu, L.-C., Lin, F.-M., Huang, H.-C (2006) "An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints." Journal of Computational Chemistry 27 :1020-1032.
  133. Horng, J.-T., Lee, T.-Y., Wu, L.-C., Huang, H.-D., Juan, H.-F., Lin, F.-M. (2005) "MultiProtIdent: Identifying Proteins Using Database Search and Protein-Protein Interactions." Journal Proteome Research 4 :690-697.
  134. Juan, H.-F.* , Chang, S.-C., Huang, H.-C., Chen, S.-T. (2005) "A New Application of Microwave Technology to Proteomics." Proteomics 5 :840-842.
  135. Wu, C.-C., Huang, H.-C., Juan, H.-F., Chen, S.-T. (2004) "GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data. " Bioinformatics 20 : 3691-3693.
  136. Chen, C.-Y., Oyang, Y.-J., Juan, H.-F. (2004) " Incremental generation of summarized clustering hierarchy for protein family analysis. " Bioinformatics 20 :2586-96.
  137. Juan, H.-F., Chen, J.-H., Hsu, W.-T., Huang, S.-C., Chen, S.-T., Lin, J. Y. C., Chang, Y.-W. Chiang, C.-Y., Wen, L.-L., Chan, D.-C., Liu, Y.-C., Chen, Y.-J. (2004) "Identification of tumor-associated plasma biomarkers using proteomic techniques: from mouse to human." Proteomics 4 : 2766-2775. ( Cover Picture )
  138. Wu, C.-Y. Jan, J.-T., Ma, H.-H., Kuo, C.-J., Juan, H.-F., Cheng, Y.-S. E., Hsu, H.-H., Huang, H.-C., Wu, D., Brik, A., Liang, F.-S., Liu, R.-S., Fang , J.-M., Chen, S.-T., Liang , P.-H. and Chi-Huey Wong (2004) "Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus." Proc. Natl. Acad. Sci. U S A 101 : 10012-10017.
  139. Juan, H.-F., Liu, H.-L., Hsu, J.-P. (2004) "Recent developments in structural proteomics: from protein identifications and structure determinations to protein-protein interactions" Current Proteomics 1 : 183-197. (Invited review paper)
  140. Chang, D. T.-H, Chen, C.-Y., Chung, W.-C., Oyang, Y.-J., Juan, H.-F., Huang, H.-C. (2004) "ProteMiner-SSM: A web server for efficient analysis of similar protein tertiary substructures" Nucleic Acids Research. 32 : W76-82.
  141. Wu, S.-F., Liu, T.-M., Lin, Y.-C., Sytwu, H.-K., Juan, H.-F., Chen, S.-T., Shen, K.-L., Hsi, S.-C., Hsieh, S.-L. (2004) "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone-marrow-derived dendritic cells in non-obese diabetic mice: From regulatory mechanism to clinical implication" Journal of Leukocyte Biology 75 : 1-14.
  142. Juan, H.-F., Lin, J. Y. C., Chang, W. H., Wu, C. Y., Pan, T. L. Tseng, M. J., Khoo, K. H. and Chen, S. T. (2002) "Biomic study of human myloid leukemia cell (HL-60) differentiated to macrophage using DNA array , proteomic, and bioinformatic analytical methods" Electrophoresis 23 : 2490 -2504.
  143. Sinchaikul, S., Sookkheo, B., Topanuruk, S., Juan, H.-F., Phutrakul, S., and Chen, S.-T. (2002) "The bioinformatics, functional genomics, and proteomics study of Bacillus sp." J. Chromatogr B 771 : 261-287.
  144. Xu, D.-H., Juan, H.-F., Nohda, M., Ban, T. (2001) “Optimization of AFLP method in wheat and its application to QTL mapping for spike characters” Breeding Research 3: 25.
  145. Juan, H.-F., Hung, C.-C., Wang, K.-T., Chiou, S.-H.* (1999) "Comparison of three classes of snake neurotoxins by homology modeling and computer simulation graphics." Biochem Biophys Res Commun. 257 : 500-510.

Book and book chapters:

  1. Juan, H.-F. (2019) "Proteomic techniques and their applications" in Biomolecular and Bioanalytical Techniques: Theory, Methodology and Applications, Edited by Vasudevan Ramesh (John Wiley & Sons, Inc., UK), pp.81-99.
  2. Siddiqui, H., Sami, F., Juan, H.-F.* and Hayat, S.* (2019) "Brassinosteroid Regulated Physiological Process: An Omics Perspective" Brassinosteroids: Plant Growth and Development, ed. By Shamsul Hayat, Dr. Mohammad Yusuf, Dr. Renu Bhardwaj & Dr. Andrzej Bajguz (Springer Nature, Singapore), pp. 297-322.
  3. Juan, H.-F. and Huang, H.-C. (2018) A Practical Guide to Cancer Systems Biology (World Scientific Publishing, Singapore)
  4. Juan, H.-F. (2017) "Data Sources for herbal and traditional medicines" in Computational Systems Pharmacology and Toxicology, Edited by Dale Johnson and Rudy J Richardson (The Royal Society of Chemistry, Cambridge, UK), pp. 243-260.
  5. Juan, H.-F. and Huang, H.-C. (2012) Systems Biology: Applications in cancer-related research (World Scientific Publishing, Singapore).
  6. Juan, H.-F. (2011) "Transcriptomics and proteomics study in regulation of brassinosteroids" in Brassinosteroids: A Class of Plant Hormone, ed. Shamsul Hayat and Aqil Ahmad (Springer, Netherlands), pp. 393-402.
  7. Juan, H.-F. and Huang, H.-C. (2007) "Bioinformatics: Microarray Data Clustering and Functional Classification" in Microarrays (2nd e ed): Applications and Data Analysis, ed. Jang B. Rampal (The humana press inc.), pp. 405-416.
  8. .陳水田、曾銘仁、阮雪芬等 (2003) 基因體科學入門, 藝軒. . [A Primer of Genome Science, Gibson, G. and Muse, S. V., Sinauer Associates Inc. (2001)]

Courses Information
  Bioinformatics
  Seminar on Systems Biology
  Genomics
 

General Biology
Copyright © 2004 Institute of Molecular and Cellular Biology, National Taiwan University

Last Updated: