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Hsueh-Ping Chu, Assistant Professor
 
Assistant Professor

Born in 1978

Ph. D. , Rutgers University, U.S.A
Postdoctoral researcher, Harvard Medical School, U.S.A

Specialty: Non-coding RNA and Epigenetics

E-mail : cchu2017@ntu.edu.tw

Laboratory: Life Science Building R807

TEL 886-2- 33662487 FAX 886-2-33662478

Recent Research Topics

•  Interactome of Non-coding RNAs

•  TERRA RNA in telomere maintenance and epigenetic regulation

Laboratory

More than 90% of the genome is transcribed into non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). LncRNAs play important roles in regulating a wide range of cellular functions and developmental processes via function critically in the cis- and trans-regulation of gene expression, epigenetic modulation in the nucleus and post-transcriptional control in the cytoplasm. The dysregulation of lncRNAs has been linked to numerous human diseases. Our laboratory uses an RNA-centric approach to reveal the network of ncRNA-protein-genome. The long-term goal is to develop a therapeutic technology for human diseases by targeting ncRNAs.


Identify RNA-protein-DNA network by RNA-capture

TElomeric Repeat containing RNA (TERRA), synthesized at the telomeric ends and highly conserved in eukaryotic cells, is a rising star lncRNA due to its crucial association with the telomere maintenance and human genetic disorders including cancer and the ICF syndrome (immunodeficiency, centromere instability, and facial anomalies). Telomeres are specialized DNA-protein structures that protect the ends of linear chromosomes and maintain genomic integrity. Studies uncovered that while TERRA plays a major role in telomere dynamics, TERRA also binds to sites throughout the genome and regulates gene expression. We are interested in the mechanisms by which TERRA regulates the telomere function and gene expression. .

Illustration of telomeric-repeat containing RNA (TERRA)

The oval image shows strand-specific staining for telomere using chromosome orientation fluorescence in situ hybridization (CO-FISH) followed by TERRA depletion. Overlapping of red and green signals indicates an event of telomere recombination.

 

Publications

1. Hsueh-Ping Chu , Catherine Cifuentes-Rojas , Barry Kesner, Eric Abey, Hyun Jung Oh, Myriam Boukhali, Wilhelm Hass, and Jeannie T. Lee. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell . 2017 June 29 Volume 170, p86-101.
[This paper was the subject of a perspective written by Roake CM, Artandi SE. Approaching TERRA Firma: Genomic Functions of Telomeric Noncoding RNA . Cell . 2017 Jun 29;170(1):8-9.]
[This paper was the subject of a perspective written by Koch L. Nat Rev Genet . 2017 Jul 17;18(8):453. Non-coding RNA : A protective role for TERRA at telomeres.

2.Hsueh-Ping Chu , Barry Kesner, John E. Froberg, Hyun Jung Oh, Stefan F. Pinter, and Jeannie T. Lee. PAR-TERRA directs homologous sex chromosome pairing. Nature Structural & Molecular Biology . 2017 July 10, doi:10.1038/nsmb.3432

3.Athanasios Zovoilis , Catherine Cifuentes-Rojas, Hsueh-Ping Chu , Alfredo J. Hernandez, and Jeannie T. Lee. Destabilization of B2 RNA by EZH2 activates the stress response. Cell . 2016 Dec 15 Volume 167, Issue 7, p1788–1802.e13

4.Yi Liao, Hsueh-Ping Chu * , Zhixain Hu, Jason J. Merkin, Jianmin Chen, Zuguo Liu, Kurt Degenhardt, Eileen White and Alexey G. Ryazanov. Paradoxical roles of elongation factor-2 kinase in stem cell survival . * CO-FIRST AUTHOR . J Biol. Chem. 2016 July 27 ( jbc.M116.724856 )

5.Hsueh-Ping Chu , Yi Liao, James S. Novak, Zhixian Hu, Jason J. Merkin, Yuriy Shymkiv, Bart P. Braeckman, Maxim V. Dorovkov, Alexandra Nguyen, Peter M, Clifford, Robert G. Nagele, David E. Harrison, Ronald E. Ellis, Alexey G. Ryazanov. Germline quality control: eEF2K stands guard to eliminate defective oocytes. Developmental Cell . 2014 Mar 10;28(5):561-72.

6.Martin A. Bewley, Trong K. Pham, Helen M. Marriott, Josselin Noirel, Hsueh-Ping Chu , Saw Y. Ow, Alexey, G. Ryazanov, Robert C.Read, Moira K. B. Whyte, Benny Chain, Phillip C. Wright and David H. Dockrell. Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococus pneumonia . Molecular & Cellular Proteomics . 2011 Jun;10 (6)M111.008193

7.Grace S. Shieh, Tsai-Hung Fan, Hsueh-Ping Chu (2008). A Bayesian approach to assessing differential expression of microarray data. Journal of Statistical Computation and Simulation , Volume 78, Issue 2 February 2008, p.179 – 191

8.Hsu-Shui Wu, Hui-Ting Lin, Chi-Kuang Leo Wang, Yen-Feng Chiang, Hsueh-Ping Chu , Meng-Chun Hu (2007) . Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads. Genesis . 2007 Feb;45(2):59-65.

9.Noomen Ben El Hadj, Meng-Chun Hu, Hsueh-Ping Chu , Leo Chi-Kuang Wang, and Bon-chu Chung (2006)- Phenotypic Analysis of Mice with Steroid Deficiency. Genetically Engineered Mice Handbook , Taylor&Francis. Edited by John P. Sundberg and Tsutomu Ichiki. Chapter 19, p253- 262, 2006.

10.Martin Heine, Catharina I. Cramm-Behrens, Athar Ansari, Hsueh-Ping Chu , Alexey G Ryazanov, Hassan Y Naim, and Ralf Jacob. Alpha-kinase 1, a new component in apical protein transport. J Biol. Chem . 2005 Jul 8;280(27):25637-43

11.Meng-Chun Hu, Nai-Chi Hsu, Noomen en El Hadj, Chin-I Pai, Hsueh-Ping Chu , Chi-Kuang Leo Wang, and Bon-Chu Chung, Steriod Deficiency Syndromes in Mice with Targeted Disruption of Cyp11A1. Mol Endocrinol , 2002.16(8)p.1943-1950.

 


Courses Information

MCB5036 Seminar in Non-coding RNAs
MCB7002 Research Training 
MCB8001 Seminar (Ph.D)
MCB5007 Molecular Cell Biology
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