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阮雪芬 教授 (Hsueh-Fen Juan, Professor)

 
職 稱 教授
出生年 1969
最高學歷 國立台灣大學博士
專 長 系統生物學、生物資訊學、蛋白質體學
E-mail yukijuan@ntu.edu.tw
研究室 生命科學館 1105 室;系統生物學研究室網頁
電話 02-33664536
傳真 02-33662478
近年研究主題

1. 以蛋白體學技術探討受異位表達 ATP 合成?運送影響之磷酸化與乙醯化交互作用動態變化
2. 生醫巨量序列資料與疾病關聯性整合平台
3. 以系統生物學探索神經母細胞瘤中重要的長鏈非編碼核糖核酸
4. 重定位藥物探索於神經母細胞瘤治療:反應機制研究

研究室簡介:系統生物學研究室

  系統生物學是在生物學上一個新興的領域,它著重於以系統的觀點來了解生物系統的運作。由於高通量藥物合成、蛋白質體、微陣列、次世代定序及生物資訊技術的發展,使得系統生物學的研究愈發可行了。生物轉變的整體研究將能加快闡明生化路徑及疾病治療的速度。除此之外,系統生物學也著重於描述和了解複雜的生物系統如何運作以及發展預測人類疾病的模式。 本研究室主要以系統生物學探討藥物在癌細胞的作用機制,內容包括各蛋白質間交互作用的預測和建構、基因網絡的模擬和建構,及微型 RNA 於其調控的蛋白質間交互作用及網路關係,期望進一步達到開發新藥的目地。 主要的目標是利用系統生物學研究法來研究在 ATP 合成酉每抑制劑誘導下乳癌及肺癌細胞進行細胞凋亡的作用機制;同時, 利用系統生物學研究法來開發新的藥物。

 

P1030172.JPG

 

代表著作

期刊論文:

  1. Liao, S.-Y., Chiang, C.-W., Hsu, C.-H., Jen, J., Juan, H.-F. , Lai, W.-W., and Wang, Y.-C. * "CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression" Oncogene (Accepted)

  2. Lin, T-.C., Chen, S.-T., Huang, M.-C., Huang, J., Hsu, C.-L., Juan, H.-F. , Lin, H.-H., Chen, C.-H. * "GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity" Oncotarget (2017 Mar 28. doi: 10.18632/oncotarget.16585)

  3. Lin, M.-C., Lin, J.-J., Hsu, C.-L., Juan, H.-F. , Lou, P.-J. * , Huang, M.-C. * "GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness" Oncogene (2017 Mar 6. doi: 10.1038/onc.2017.8)

  4. Chang, H.-H., Liu, Y.-L., Lu, M.-Y., Jou, S.-T., Yang, Y.-L., Lin, D.-T., Lin, K.-H., Tzen, K.-Y. Yen, R.-F., Lu, C.-C., Liu, C.-J., Peng, S. S.-F., Jeng, Y.-M., Huang, S.-F., Lee, H., Juan, H.-F. , Huang, M.-C., Liao, Y.-F., Lee, Y.-L. * , Hsu, W.-M. * (2017) "A multidisciplinary team care approach to improving outcomes in pediatric patients with high-risk neuroblastoma" Oncotarget 8(3):4360-72.

  5. Wang, Y.-T., Chiang, H.-H., Huang, Y.-S., Hsu, C.-L. , Yang, P.-J., Juan, H.-F. , Yang, W.-S. * (2016) "A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA" Cell Death and Disease 7(11):e2458.

  6. Wu, C.-H., Hsu, C.-L., Lu, P.-C., Lin, W.-C., Juan, H.-F. * , Huang, H.-C. * (2016) "Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules" Scientific Reports 6:35939.

  7. Sahu, D., Hsu, C.-L., Lin, C.-C., Yang, T.-W., Hsu, W.-M., Ho, S.-Y., Juan, H.-F. * , Huang, H.-C. * (2016) "Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma" Oncotarget 9(36): 58022-37.

  8. Hsu, C.-L., Chang, H.-Y., Chang, J.-Y., Hsu, W.-M., Huang, H.-C. * and Juan, H.-F. * (2016) "Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data" Oncotarget 7(24):36293-310.

  9. Lin, M.-T., Wang, C.-Y., Xie, H.-J., Cheung, C. H. Y., Hsieh, C.-H., Juan, H.-F. , Chen, B.-S.,  C. Lin * (2016) "Novel utilization of terminators in the design of biologically adjustable synthetic filters" ACS Synthetic Biology 5(5):365-74.

  10. Jen, J., Lin, L.-L., Lo, F.-Y., Chen, H.-T., Liao, S.-Y., Tang, Y.-A., Hsu, H.-S., Salgia, R., Hsu, C.-L., Huang, H.-C., Juan, H.-F. * , Wang, Y.-C. * (2016) "Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer" Oncogene 35(18):2357-69.

  11. Liu, S.-Y., Shun, C.-T., Hung, K.-Y., Juan, H.-F. , Hsu, C.-L., Huang, M.-C. * , Lai, I-R. * (2016) "Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation" Oncotarget 7(10):11251-62.

  12. Klionsky, D.-J., et al. (2016) “Guidelines for the use and interpretation of assays for monitoring autophagy”  Autophagy  12(1):1-222.
  13. Hu, C.-W., Hsu, C.-L., Wang, Y.-C., Ishihama, Y., Ku, W-C., Huang, H.-C.* and  Juan, H.-F. * (2015) “Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin”  Molecular & Cellular Proteomics 14 (12):3284-98.
  14. Hsu, C.-L., Juan, H.-F. * , and Huang, H.-C. * (2015) " Characterization and functional analysis of differential coexpression networks " Scientific Reports 5:13295.
  15. Lin, L.-L., Hsu, C.-L., Hu, C.-W., Ko, S.-Y., Hsieh, H.-L., Huang, H.-C. * , Juan, H.-F. * (2015) "Integrating phosphoproteomics and bioinformatics to study brassinosteroid-regulated phosphorylation dynamics in Arabidopsis " BMC Genomics 16:533. ( Highly accessed )
  16. Lin, L.-L., Huang, H.-C. * , Juan, H.-F. * (2015) "Circadian systems biology in metazoa" Briefings in Bioinformatics (Mar 10 online)
  17. Huang, M.-J., Hu, R.-H., Chou, C.-H., Hsu, C.-L., Liu, Y.-W., Huang, J., Hung, J.-S., Lai, I-R., Juan, H.-F. , Yu, S.-L., Wu, Y.-M. * and Huang, M.-C. * (2015) "Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling" Oncotarget 6(8):5650-65.
  18. Lee, A. Y.-L. * , Chiu, Y.-C., Fang, W.-C., Cheng, C.-W., Kuo, C.-Y., Juan, H.-F. , Wu, S.-H. * and Kao, T.-Y. * (2015) "Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex" Cell Death & Disease 6:e1642.
  19. Lin, L.-L., Hsia, C.-R., Hsu, C.-L., Huang, H.-C. * and Juan, H.-F. * (2015) "Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells" BMC Genomics 16(1):41.
  20. Chang, H.-Y., Li, M.-H., Huang, T.-C., Hsu, C.-L., Tsai, S.-R., Lee, S.-C. * , Huang, H.-C. * and Juan, H.-F. * (2015) "Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells" Journal of Proteome Research 14(2):1250-62.
  21. Chang, H.-Y., Huang, T.-C., Chen, N.-N., Huang, H.-C. * and Juan, H.-F. * (2014) "Combination therapy targeting ectopic ATP synthase and 26s proteasome induces ER stress in breast cancer cells" Cell Death & Disease 5:e1540.
  22. Chen, C.-Y., Ho, A., Huang, H.-Y.,  Juan, H.-F. * and Huang, H.-C.* (2014)  " Dissecting the human protein-protein interaction network via phylogenetic decomposition "    Scientific Reports  4:7153 .
  23. Huang, C.-T., Oyang, Y.-J., Huang, H.-C. * and Juan, H.-F. * (2014) "MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma" Scientific Reports 4:6495.
  24. Lin, L.-L., Huang, H.-C. * , Juan, H.-F. * (2014) " Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approaches " Drug Discovery Today 19(9):1402-1409.
  25. Yang, K.-C., Hsu, C.-L., Lin, C.-C., Juan, H.-F. * and Huang, H.-C. * (2014) " Mirin: identifying microRNA regulatory modules in protein-protein interaction networks " Bioinformatics 30(17):2527-2528.
  26. Chen. C.-M., Chen, I.-C., Huang, Y.-C., Juan, H.-F. , Chen, Y.-L., Chen, Y.-C., Lin, C.-H., Lee, L.-C., Lee, C.-M., Lee-Chen, G.-J., Lai, Y.-J., and Wu, Y.-R. (2014) "FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease" PLoS ONE 9(7):e101392.
  27. Hsieh, L.-C., Chen, J.-W., Wang, L.-Y., Tsang, Y.-M., Shueng, P.-W., Liao, L.-J., Lo, W.-C., Lin, Y.-C., Tseng, C.-F., Kuo, Y.-S., Jhuang, J.-Y., Tien, H.-J., Juan, H.-F. , Hsieh, C.-H. (2014) "Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging" PLoS ONE 9(3):e92561.
  28. Huang, W.-J., Tang, Y.-A., Chen, M.-Y, Wang, Y.-J., Hu, F.-H., Wang, T.-W., Chao, S.-W. Chiu, H.-W., Yeh, Y.-L., Chang, H.-Y., Juan, H.-F. , Lin, P. * , and Wang, Y.-C. * (2014) "A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies" Cancer Letter 346(1):84-93.
  29. Wu, P.-Y., Liao, Y.-F., Juan, H.-F. , Huang, H.-C., Wang, B.-J., Lu, Y.-L., Yu, I-S., Shih, Y.-Y., Jeng, Y.-M., Hsu, W.-M. * , and Lee, H. * (2014) "Aryl hydrocarbon receptor downregulates mycn expression and promotes cell differentiation of neuroblastoma" PLoS ONE 9(2): e88795.
  30. Chang, H.-Y., Shih, M.-H., Huang, H.-C., Tsai, S.-R., Juan, H.-F. * , Lee, S.-C. * (2013) "Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells" PLoS ONE 8(1): e54117. ( Featured on PLoS Blog )
  31. Hu, C.-W., Tseng, C.-W., Chien, C.-W., Huang, H.-C., Ku, W.-C., Lee, S.-J. * , Chen, Y.-J. * and Juan, H.-F. * (2013) "Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development" Journal of Proteome Research 12(9):3993-4004.
  32. Wu, Y.-H., Hu, C.-W., Chien, C.-W., Chen, Y.-J., Huang, H.-C.* and Juan, H.-F.* (2013) "Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin" PLoS ONE 8(8):e70642.
  33. Lin, L.-L., Wu, C.-C., Huang, H.-C. * , Chen, H.-J. Hsieh, H.-L. * , and Juan, H.-F. * (2013) "Identification of microRNA 395a in 24-epibrassinolide-regulated root growth of Arabidopsis thaliana using microRNA arrays" International Journal of Molecular Sciences 14:14270-14286.
  34. Lin, C.-C., Lee, C.-H., Fuh, C.-S., Juan, H.-F. * and Huang, H.-C. * (2013) "Link clustering reveals structural characteristics and biological contexts in signed molecular networks" PLoS ONE 8(6): e67089.
  35. Lee, C.-H., Kuo, W.-H., Lin, C.-C., Oyang, Y.-J., Huang, H.-C. * and Juan, H.-F. * (2013) "MicroRNA-regulated protein-protein interaction networks and their functions in breast cancer" International Journal of Molecular Sciences 14:11560-11606.
  36. Liaw, H.-H., Lin, C.-C., Juan, H.-F. * and Huang, H.-C. * (2013) "Differential microRNA regulation correlates with alternative polyadenylation pattern between breast cancer and normal cells" PLoS ONE 8(2): e56958.
  37. Fu, S.-C., Huang, H.-C., Horton, P.* and Juan, H.-F. * (2013) "ValidNESs: a database of validated leucine-rich nuclear export signals" Nucleic Acids Research 41(D1):D338-D343.
  38. Lin, L.-L., Huang, H.-C., Ogihara, S., Wang, J.-T., Wu, M.-C., McNeil, P. L. * , Chen, C.-N. * and Juan, H.-F. * (2012) " Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation" International Journal of Molecular Sciences 13 : 10176-10192.
  39. Lin, L.-L., Huang, H.-C. * , and Juan, H.-F. * (2012) "Revealing the molecular mechanism of gastric cancer marker Annexin A4 in cancer cell proliferation using exon arrays" PLoS ONE 7(9):e44615.
  40. Chang, H.-Y., Huang, H.-C., Huang, T.-C., Yang, P.-C.*, Wang, Y.-C.*, and Juan, H.-F. * (2012) "Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response" Cancer Research 72(18): 4696-4706.
  41. Lin, L.-L., Huang, H.-C. * and Juan, H.-F. * (2012) "Discovery of biomarkers for gastric cancer: a proteomics approach" Journal of Proteomics 75(11):3081-3097.
  42. Chang, M.-W., Lo, J.-M., Juan, H.-F. , H.-Y. Chang, Chuang, C.-Y. (2012) " Combination of RGD Compound and Low-Dose Paclitaxel Induces Apoptosis in Human Glioblastoma Cells " PLoS ONE 7(5):e37935
  43. Tseng, C.-W., Huang, H.-C., Shih, A. C.-C., Chang, Y.-Y., Hsu, C. C., Chang, J.-Y., Li, W.-H. * and Juan, H.-F. * (2012) "Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D" International Journal of Molecular Sciences 13 :6352-6369.
  44. Lin, C.-C., Chen, Y.-J., Chen, C.-Y., Oyang, Y.-J., Juan, H.-F. * and Huang, H.-C. * (2012) "Crosstalk between transcription factors and microRNAs in human protein interaction network" BMC Systems Biology 6(1):18.
  45. Shih, Y.-Y., Nakagawara, A., Lee, H., Juan, H.-F. , Jeng, Y.-M., Lin, D.-T., Yang, Y.-L., Tsay, Y.-G., Huang, M.-C., Pan, C.-Y. * , Hsu, W.-M. * , and Liao, Y.-F. * (2012) "Calreticulin mediates nerve growth factor-induced neuronal differentiation" Journal of Molecular Neuroscience 47(3):571-81.
  46. Chen, C.-Y., Chen, S.-T., Juan, H.-F. * and Huang, H.-C. * (2012) "Lengthening of 3'UTR increases morphological complexity in animal evolution" Bioinformatics 28(24):3178-3181. (ESI 2013 Highly cited papers) .
  47. Lu, K.-Y., Tao, S.-C., Yang, T.-C., Ho, Y.-H., Lee, C.-H., Lin, C.-C., Juan, H.-F. , Huang, H.-C. , Yang, C.-Y., Chen, M,-S, Zhu, H. * and Chen, C.-S. * (2012) "Profiling lipid-protein interactions using non-quenched fluorescent liposomal nanovesicles and proteome microarrays" Molecular & Cellular Proteomics 11(11):1177-1190.
  48. Hu, C.-W., Lin, M.-H., Huang, H.-C., Ku, W.-C., Yi, T.-H., Tsai, C.-F., Chen, Y.-J., Sugiyama, N., Ishihama, Y. * , Juan, H.-F. * , and Wu, S.-H. * (2012) "Phosphoproteomic analysis of Rhodopseudomonas palustris reveals the role of pyruvate phosphate dikinase phosphorylation in lipid production" Journal of Proteome Research 11:5362-5375.
  49. Lin, L.-L., Wang, Y.-H., Lai, C.-Y., Chau, C.-L., Su, G.-C., Yang, C.-Y., Lou, S.-Y., Chen, S.-K., Hsu, K.-H., Lai, Y.-L., Wu, W.-M., Huang, J.-L., Liao, C.-H. and Juan, H.-F. * (2012) "Systems biology of meridians, acupoints, and Chinese herbs in disease" Evidence-Based Complementary and Alternative Medicine 2012:372670.
  50. Hu, C.-W., Chang, Y.-L., Chen, S. J., Kuo-Huang, L.-L., Liao, J. C., Huang, H.-C.*, Juan, H.-F.* (2011) "Revealing the functions of the transketolase enzyme isoforms in Rhodopseudomonas palustris using a systems biology approach" PLoS ONE 6:e28329.
  51. Huang, T.-C., Chang, H.-Y., Chen, C.-Y., Wu, P.-Y., Lee, H., Liao, Y.-F., Hsu, W.-M.*, Huang, H.-C.*, Juan, H.-F.* (2011) "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR" FEBS Letters 585:3582-3586.
  52. Tsai, S.-R.#, Huang, T.-C.#, Liang, C.-M., Chang, H.-Y., Chang, Y.-T., Huang, H.-C., Juan, H.-F.*, Lee, S.-C.* (2011) "The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli" Applied Physics Letters 99, 163704. (# equal contribution)
  53. Shih, Y.-Y., Pan, C,-Y, Lee, H., Juan, H.-F., A. Nakagawara, Clagett-Dame, M., Tsay, Y.-G., Hsieh, F.-J., Hsu, W.-M.*, Liao, Y.-F. * (2011) "Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma" PLoS ONE 6(10):e26236
  54. Chen, S.-T., Jeng, Y.-M., Chang, C.-C., Chang, H.-H., Huang, M.-C., Juan, H.-F., Hsu, C.-H., Lee, H.-Y., Liao, Y.-F, Lee, Y.-L., Hsu, W.-M.*, Lai, H.-S.* (2011) "Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma" Cancer Science 102:2191-2198.
  55. Lee, C.-H., Huang, H.-C. * , Juan, H.-F. * (2011) "Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor" International Journal of Molecular Sciences 12, 5304-5318.
  56. Chen, C.-M., Lin, C.-H., Juan, H.-F. , Hu, F.-J., Hsiao, Y.-C., Chang, H.-Y., Chao, C.-Y., Chen, I.-C., Lee, L.-C., Wang, T.-W., Chen, Y.-T., Chen, Y.-T., Lee-Chen, G.-J. * , Wu, Y.-R. (2011) ATP13A2 variability in Taiwanese Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 156:720-729.
  57. Tseng, C.-W., Lin, C.-C., Chen, C.-N. * , Huang, H.-C. * , Juan, H.-F. * (2011) "Integrative network analysis reveals active microRNAs and their functions in gastric cancer" BMC Systems Biology 5:99.
  58. Tseng, C.-W., Yang, J.-C., Chen, C.-N. * , Huang, H.-C., Chuang, K.-N., Lin, C.-C., Lai, H.-S., Lee, P.-H., Chang, K.-J., Juan, H.-F. * (2011) " Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker " Proteomics 11:2423-2439.
  59. Chen, J.-Y., Huang, S.-M., Tang, Y.-A., Juan, H.-F. , Wu, L.-W., Sun, Y.-C., Wang, S.-C., Wu, K. W., Balraj, G., Chang, T.-T., Li, W.-S. * , Cheng, H.-C. * , Wang, Y.-C. * (2011) "A novel sialyltransferase inhibitor suppresses FAK/paxillin and angiogenesis signaling and cancer metastasis" Cancer Research 71:473-483.
  60. Chen, C-Y, Chen, S.-T., Fuh, C.-S. Juan, H.-F. * , Huang H.-C. * (2011) "Coregulation of Transcription Factors and microRNAs in Transcriptional Regulatory Network" BMC Bioinformatics 12(Suppl 1):S41.
  61. Lin, C.-C., Hsiang, J.-T., Wu, C.-Y., Oyang, Y.-J., Juan, H.-F. * , Huang H.-C. * (2010) "Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy" BMC Systems Biology 4:138.
  62. Chang, H.-H., Lee, H.-Y., Hu, M.-K., Tsao, P.-N., Juan, H.-F. , Huang, M.-C., Shih, Y.-Y., Wang, B.-J., Jeng, Y.-M., Chang, C., Huang, S.-F., Y.-G. Tsay, Hsieh, F.-J., Lin, K.-H. * , Hsu, W.-M. * , and Liao, Y.-F * . (2010) "Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma" Clinical Cancer Research 16:4411-4420.
  63. Hsu, J.-W., Huang H.-C. , Chen, S.-T., Wong, C.-H. , Juan, H.-F. * (2009) " Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation" Evidence-Based Complementary and Alternative Medicine ; doi: 10.1093/ecam/nep107
  64. Hwang Y.-C., Lin C.-C., Chang J.-Y., Mori H., Juan, H.-F. * , Huang H.-C. * (2009) "Predicting essential genes based on network and sequence analysis" Molecular BioSystems 5:1672–1678.
  65. Lin, C.-C., Juan, H.-F. , Hsiang, J.-T., Hwang, Y.-C., Mori, H. * , Huang, H.-C. * (2009) "Essential core of protein-protein interaction network in Escherichia coli " Journal of Proteome Research 8(4):1925-1931.
  66. Chang, Y.-M., Juan, H.-F. , Lee, T.-Y., Chang, Y.-Y., Yeh, Y.-M., Li, W.-H. * , Shih, A. C.-C. (2008) "Prediction of human miRNAs using tissue-selective motifs in 3' UTRs" Proc. Natl. Acad. Sci. U S A 105, 17061-17066. ( Highlighted in Nature Biotechnology and in Science-Business eXchange (SciBX) )
  67. Fang, Y.-C., Huang, H.-C. , Chen, H.-H. and Juan, H.-F. * (2008) "TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining" BMC Complementary and Alternative Medicine 8:58.
  68. W.-M. Hsu, H.-Y. Lee, Juan, H.-F. , Y.-Y. Shih, B-J. Wang, C.-Y. Pan, Y.-M. Jeng, H.-H. Chang, M.-Y. Lu, K.-H. Lin, H.-S. Lai, W.-J. Chen, Y.-G. Tsay * , Y.-F. Liao * , F.-J. Hsieh * (2008) "Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis" Clinical Cancer Research 14:6237-6245.
  69. Hsu, C.-W., Juan, H.-F. * , Huang, H.-C. * (2008) "Characterization of microRNA-Regulated Protein-Protein Interaction Network" Proteomics 8:1975-1979.
  70. Lin, L.-L., C.-N. Chen*, Lin, W.-C., Lee, P.-H., Chang, K.-J., Lai, Y.-P., Wang, J.-T., Juan, H.-F. * (2008) "Annexin A4: A novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach " Proteomics: clinical applications 2:619-634.
  71. Chen, S.-T., Pan, T.-L., Juan, H.-F. , Chen, T.-Y., Lin, Y.-S., Huang, C.-M. * (2008) "Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome and Extracellular Matrix" Journal of Proteome Research 7:1379-1387.
  72. Huang, T.-C., Chang, H.-Y., Hsu, C.-H., Kuo, W.-H., Chang, K.-J., Juan, H.-F. * (2008) "Targeting Therapy on Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B" Journal of Proteome Research 7:1433-1444. ( Science Daily news & American Chemical Society weekly news )
  73. Chen, H.-W., Huang, H.-C., Lin, Y.-S., Chang, K.-J., Kuo, W.-H., Hwa, H.-L., Hsieh, F.-J. * , Juan, H.-F. * (2008) "Comparison and Identification of Estrogen-Receptor Related Gene Expression Profiles in Breast Cancer of Different Ethnic Origins" Breast Cancer: Basic and Clinical Research 1:35-49.
  74. Tan, Y-H., Lee, K.-H., Sun, Y.-C., Juan, H.-F. * , Y.-C. Wang * (2008) "Cytotoxicity and proteomics analyses of OSU 03013 in lung cancer" Clinical Cancer Research 14:1823-1830.
  75. Fang, Y.-C., Huang, H.-C. * , Juan, H.-F. * (2008) "MeInfoText: Associated Gene Methylation and Cancer Information from Text Mining" BMC Bioinformatics 9:22.
  76. Huang, B., Ni, K.-C., Chen, S.-L., Juan, H.-F. * , Chen Y.-M. * (2008) "Elucidating the Growth Regulation of Brassinosteroids in Mung Bean Epicotyls using a Proteomics Approach" Proteomics Research Journal 1: 1-18.
  77. Lien, H.-C., Hsiao, Y.-H., Lin, Y.-S., Yao , Y.-T., Juan, H.-F. , Kuo, W.-H., Hung, M.-C., Chang, K.-J., Hsieh, F.-J. * (2007) "Molecular Signatures of Metaplastic Carcinoma of the Breast by Large-Scale Transcriptional Profiling: Identification of Genes Potentially Related to Epithelial-Mesenchymal Transition." Oncogene 26:7859-7871.
  78. Cheng, K.-C., Huang, H.-C., Chen, J.-H., Hsu, J.-W., Cheng, H.-C., Ou, C.-H., Yang, W.-B., Chen, S.-T., Wong, C.-H. and Juan, H.-F. * (2007) " Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction" BMC Genomics 8:411.
  79. Huang, T.-C., Huang, H.-C., Chang, C.-C., Chang, H.-Y., Ou, C.-H., Hsu, C.-H., Chen, S.-T. and Juan, H.-F. * (2007) "An Apoptosis-related Gene Network Induced by Novel Compound-cRGD in Human Breast Cancer Cells." FEBS Letters 581:3517-3522.
  80. Leu, J.-H., Chang, C.-C., Wu, J.-L., Hsu, C.-W., Hirono, I. , Aoki, T., Juan, H.-F. , Lo, C.-F., Kou, G.-H. * , Huang H.-C. * (2007) "Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon ." BMC Genomics 8:120.
  81. Fang, Y.-C., Sun, W.-H.*, Wu, L.-C., Huang, H.-D., Juan, H.-F. , Horng, J.-T.* (2006) "RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling." BMC Genomics 7 :317.
  82. Tseng, H.-W., Juan, H.-F. , Huang, H.-C., Lin, J. Y.-C., Sinchaikul, S., Chen , C.-F., Chen, S.-T. * , Wang * , G.-J. (2006) "A systems biology study of lipopolysaccharide-stimulated responses in rat aortic endothelial cell." Proteomics 6 :5915-5928.
  83. Chen, Y.-R., Juan, H.-F. , Huang, H.-C., Huang, H.-H., Lee, Y.-J., Liao, M.-Y., Tseng, C.-W., Lin, L.-L., M.-Y. Chen, J.-Y., Wang, M.-J., J.-H. Chen * , Y.-J. Chen * (2006) "Quantitative Proteomic and Genomic Profiling Reveals Metastasis-Related Protein Expression Patterns in Gastric Cancer Cells." Journal Proteome Research 5 :2727-2742.
  84. Huang, B., Chu , C.-H., Chen, S.-L., Juan, H.-F. * and Chen, Y.-M. * (2006) "Proteomics Study of Mung Bean Epicotyl Regulated by Brassinosteroid under Chilling Condition." Cellular & Molecular Biology Letters 11 :264-278.
  85. Juan, H.-F. * , Wang, I-H., Huang, T.-C., Li, J.-J., Chen, S.-T., Huang, H.-C. (2006) " Proteomics analysis of a novel compound – cyclic RGD in breast carcinoma cell line MCF-7. " Proteomics 6 :2991-3000. ( Cover Picture )
  86. Lee, T.-Y., Horng, J.-T., Juan, H.-F. , Huang, H.-D., Wu, L.-C., Lin, F.-M., Huang, H.-C (2006) "An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints." Journal of Computational Chemistry 27 :1020-1032.
  87. Horng, J.-T., Lee, T.-Y., Wu, L.-C., Huang, H.-D., Juan, H.-F. , Lin, F.-M. (2005) "MultiProtIdent: Identifying Proteins Using Database Search and Protein-Protein Interactions." Journal Proteome Research 4 :690-697.
  88. Juan, H.-F. * , Chang, S.-C., Huang, H.-C., Chen, S.-T. (2005) "A New Application of Microwave Technology to Proteomics." Proteomics 5 :840-842.
  89. Wu, C.-C., Huang, H.-C., Juan, H.-F. , Chen, S.-T. (2004) " GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data. " Bioinformatics 20 : 3691-3693.
  90. Chen, C.-Y., Oyang, Y.-J., Juan, H.-F. (2004) " Incremental generation of summarized clustering hierarchy for protein family analysis. " Bioinformatics 20 :2586-96.
  91. Juan, H.-F. , Chen, J.-H., Hsu, W.-T., Huang, S.-C., Chen, S.-T., Lin, J. Y. C., Chang, Y.-W. Chiang, C.-Y., Wen, L.-L., Chan, D.-C., Liu, Y.-C., Chen, Y.-J. (2004) "Identification of tumor-associated plasma biomarkers using proteomic techniques: from mouse to human." Proteomics 4 : 2766-2775. ( Cover Picture )
  92. Wu, C.-Y. Jan, J.-T., Ma, H.-H., Kuo, C.-J., Juan, H.-F. , Cheng, Y.-S. E., Hsu, H.-H., Huang, H.-C., Wu, D., Brik, A., Liang, F.-S., Liu, R.-S., Fang , J.-M., Chen, S.-T., Liang , P.-H. and Chi-Huey Wong (2004) "Small molecules targeting Severe Acute Respiratory Syndrome (SARS) human coronavirus." Proc. Natl. Acad. Sci. U S A 101 : 10012-10017.
  93. Juan, H.-F. , Liu, H.-L., Hsu, J.-P. (2004) "Recent developments in structural proteomics: from protein identifications and structure determinations to protein-protein interactions" Current Proteomics 1 : 183-197. (Invited review paper)
  94. Chang, D. T.-H, Chen, C.-Y., Chung, W.-C., Oyang, Y.-J., Juan, H.-F. , Huang, H.-C. (2004) "ProteMiner-SSM: A web server for efficient analysis of similar protein tertiary substructures" Nucleic Acids Research. 32 : W76-82.
  95. Wu, S.-F., Liu, T.-M., Lin, Y.-C., Sytwu, H.-K., Juan, H.-F. , Chen, S.-T., Shen, K.-L., Hsi, S.-C., Hsieh, S.-L. (2004) "Immunomodulatory effect of decoy receptor 3 on the differentiation and function of bone-marrow-derived dendritic cells in non-obese diabetic mice: From regulatory mechanism to clinical implication" Journal of Leukocyte Biology 75 : 1-14.
  96. Juan, H.-F. , Lin, J. Y. C., Chang, W. H., Wu, C. Y., Pan, T. L. Tseng, M. J., Khoo, K. H. and Chen, S. T. (2002) "Biomic study of human myloid leukemia cell (HL-60) differentiated to macrophage using DNA array , proteomic, and bioinformatic analytical methods" Electrophoresis 23 : 2490 -2504.
  97. Sinchaikul, S., Sookkheo, B., Topanuruk, S., Juan, H.-F. , Phutrakul, S., and Chen, S.-T. (2002) "The bioinformatics, functional genomics, and proteomics study of Bacillus sp." J. Chromatogr B 771 : 261-287.
  98. Xu, D.-H., Juan, H.-F. , Nohda, M., Ban, T. (2001) “Optimization of AFLP method in wheat and its application to QTL mapping for spike characters” Breeding Research 3: 25.
  99. Juan, H.-F ., Hung, C.-C., Wang, K.-T., Chiou, S.-H.* (1999) "Comparison of three classes of snake neurotoxins by homology modeling and computer simulation graphics." Biochem Biophys Res Commun. 257 : 500-510.

專書及專書論文:

  1. Juan, H.-F. and Huang, H.-C. (2012) Systems Biology: Applications in cancer-related research (World Scientific Publishing, Singapore).
  2. Juan, H.-F. and Huang, H.-C. (2007) "Bioinformatics: Microarray Data Clustering and Functional Classification" in Microarrays (2nd ed): Applications and Data Analysis, ed. Jang B. Rampal (The humana press inc.), pp. 401-414.
  3. 陳水田、曾銘仁、阮雪芬等 (2003) 基因體科學入門, 藝軒. [A Primer of Genome Science, Gibson, G. and Muse, S. V., Sinauer Associates Inc. (2001)]
 
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P15 U2020 系統生物學
B43 M0370 系統生物學專題討論
B43 U1230

生物資訊學

P05 U2020 生物技術核心實驗

 

普通生物學
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